(S)-(-)-2-(Boc-氨基)-3-苄氧基-1-丙醇合成路线 （共 25 条）
反应条件
1.1: sodium hydride / N,N-dimethyl-formamide / 0 °C / Inert atmosphere 1.2: 25 °C / Inert atmosphere 2.1: 4-methyl-morpholine; isobutyl chloroformate / ethylene glycol dimethyl ether / -20 °C 2.2: 0.5 h / Cooling with ice View Scheme
参考文献
WO2011/69149 A2, ;
WO 2011/069149 A1
反应条件
1: 98 percent / BF3*Et2O / acetone / 2 h / Ambient temperature 2: 95 percent / H2 / Pd/C / ethyl acetate / 24 h / Ambient temperature 3: 93 percent / Dess-Martin periodinane / CH2Cl2 / 2 h / Ambient temperature View Scheme
参考文献
Avenoza; Cativiela; Corzana; Peregrina; Zurbano
Synthesis, 1997 , # 10 p. 1146 - 1150
反应条件
1: 88 percent / BF3*OEt2 / 0 °C 2: 95 percent / H2 / Pd/C / methanol View Scheme
参考文献
Avenoza; Cativiela; Corzana; Peregrina; Zurbano
Synthesis, 1997 , # 10 p. 1146 - 1150
反应条件
1: 99 percent / triethylamine / CH2Cl2 / -3 °C 2: NaH / tetrahydrofuran / Heating 3: 100 percent / Raney Ni / ethanol; H2O / Heating View Scheme
参考文献
Donner
Tetrahedron Letters, 1995 , vol. 36, # 8 p. 1223 - 1226
反应条件
1: 99 percent / triethylamine / CH2Cl2 / -3 °C 2: NaH / tetrahydrofuran / Heating 3: 100 percent / Raney Ni / ethanol; H2O / Heating View Scheme
参考文献
Donner
Tetrahedron Letters, 1995 , vol. 36, # 8 p. 1223 - 1226
