1-苄基-4-(1,2,3,4-四氢-2-氧代-3-喹唑啉yl)哌啶合成路线 （共 14 条）
反应条件
1: 83.1 percent / hydrogen, 1 N aq.HCl / 10percent Pd-C / methanol / 5 h / 40 °C
2: 64.9 percent / TEA / methanol / Ambient temperature
3: 63.4 percent / NaBH4 / methanol / 5 h / Ambient temperature
View Scheme
参考文献
Takai; Obase; Nakamizo; Teranishi; Kubo; Shuto; Kasuya; Shigenobu; Hashikami; Karashima
Chemical and Pharmaceutical Bulletin, 1985 , vol. 33, # 3 p. 1116 - 1128
反应条件
1: 83.1 percent / hydrogen, 1 N aq.HCl / 10percent Pd-C / methanol / 5 h / 40 °C
2: 55.8 percent / TEA / methanol / Ambient temperature
3: 58.9 percent / NaBH4 / methanol / 5 h / Ambient temperature
View Scheme
参考文献
Takai; Obase; Nakamizo; Teranishi; Kubo; Shuto; Kasuya; Shigenobu; Hashikami; Karashima
Chemical and Pharmaceutical Bulletin, 1985 , vol. 33, # 3 p. 1116 - 1128
反应条件
1: 83.1 percent / hydrogen, 1 N aq.HCl / 10percent Pd-C / methanol / 5 h / 40 °C
2: 66.5 percent / TEA / methanol / Ambient temperature
3: 52 percent / NaBH4 / methanol / 5 h / Ambient temperature
View Scheme
参考文献
Takai; Obase; Nakamizo; Teranishi; Kubo; Shuto; Kasuya; Shigenobu; Hashikami; Karashima
Chemical and Pharmaceutical Bulletin, 1985 , vol. 33, # 3 p. 1116 - 1128
反应条件
1: 83.1 percent / hydrogen, 1 N aq.HCl / 10percent Pd-C / methanol / 5 h / 40 °C
2: 48 percent / TEA / methanol / Ambient temperature
3: 56.6 percent / NaBH4 / methanol / 5 h / Ambient temperature
View Scheme
参考文献
Takai; Obase; Nakamizo; Teranishi; Kubo; Shuto; Kasuya; Shigenobu; Hashikami; Karashima
Chemical and Pharmaceutical Bulletin, 1985 , vol. 33, # 3 p. 1116 - 1128
