N-(2-(氨基甲基)苯基)-1-苄基哌啶-4-胺合成路线 （共 6 条）
反应条件
trifluoroacetic acid in chloroform
参考文献
Merck and Co., Inc.
Patent: US5665719 A1, 1997 ;
US 5665719 A
反应条件
lithium aluminium tetrahydride in 1,4-dioxane
6 h; Heating;
参考文献
Takai; Obase; Nakamizo; Teranishi; Kubo; Shuto; Kasuya; Shigenobu; Hashikami; Karashima
Chemical and Pharmaceutical Bulletin, 1985 , vol. 33, # 3 p. 1116 - 1128
反应条件
lithium aluminium tetrahydride in 1,4-dioxane
Heating;
参考文献
Goehring, R. Richard; Whitehead, John F.W.; Brown; Islam, Khondaker; Wen, Xin; Zhou, Xiaoming; Chen, Zhengming; Valenzano, Kenneth J.; Miller, Wendy S.; Shan, Shen; Kyle, Donald J.
Bioorganic and Medicinal Chemistry Letters, 2004 , vol. 14, # 20 p. 5045 - 5050
反应条件
1: 58 percent / NaBH(OAc)3; AcOH / 1,2-dichloro-ethane
2: 71 percent / LiAlH4 / dioxane / Heating
View Scheme
参考文献
Goehring, R. Richard; Whitehead, John F.W.; Brown; Islam, Khondaker; Wen, Xin; Zhou, Xiaoming; Chen, Zhengming; Valenzano, Kenneth J.; Miller, Wendy S.; Shan, Shen; Kyle, Donald J.
Bioorganic and Medicinal Chemistry Letters, 2004 , vol. 14, # 20 p. 5045 - 5050
反应条件
in 1,4-dioxane; (2S)-N-methyl-1-phenylpropan-2-amine hydrate; chloroform; water; benzene
参考文献
Kyowa Hakko Kogyo Co., Ltd.
Patent: US4344945 A1, 1982 ;
反应条件
1: 58 percent / NaBH(OAc)3; AcOH / 1,2-dichloro-ethane
2: 71 percent / LiAlH4 / dioxane / Heating
View Scheme
参考文献
Goehring, R. Richard; Whitehead, John F.W.; Brown; Islam, Khondaker; Wen, Xin; Zhou, Xiaoming; Chen, Zhengming; Valenzano, Kenneth J.; Miller, Wendy S.; Shan, Shen; Kyle, Donald J.
Bioorganic and Medicinal Chemistry Letters, 2004 , vol. 14, # 20 p. 5045 - 5050
