N-叔丁氧羰基-4-哌啶酮合成路线 （共 500 条）
反应条件
sodium hydrogencarbonate in water 1) 35 deg C, 1 h; 2) 50 deg C, 2.5 h;
参考文献
COMMONWEALTH SCIENTIFIC AND INDUSTRIAL RESEARCH ORGANISATION; YANG, Qi; JAMES, Susan N.; BALLARD, Mathew John; BOWN, Mark; FERON, Paul; PUXTY, Graeme Douglas
Patent: WO2012/142668 A1, 2012 ;
Location in patent: Page/Page column 50; 51 ;
反应条件
[Ni0(1,5-cyclooctadiene)2]; potassium tert-butylate; 1,3-bis(2,6-diisopropylphenyl)imidazolinium chloride in 2,4-dichlorotoluene T=25°C; 0.5 h; Inert atmosphere;
参考文献
Berini, Christophe; Winkelmann, Ole H.; Otten, Jennifer; Vicic, David A.; Navarro, Oscar
Chemistry - A European Journal, 2010 , vol. 16, # 23 p. 6857 - 6860
反应条件
triethylamine in dichloromethane T=20°C; 16 h;
参考文献
Fan, Xing; Zhang, Feng-Hua; Al-Safi, Rasha I.; Zeng, Li-Fan; Shabaik, Yumna; Debnath, Bikash; Sanchez, Tino W.; Odde, Srinivas; Neamati, Nouri; Long, Ya-Qiu
Bioorganic and Medicinal Chemistry, 2011 , vol. 19, # 16 p. 4935 - 4952
反应条件
potassium hydrogencarbonate in chloroform T=20°C;
参考文献
XENON PHARMACEUTICALS INC.
Patent: WO2006/34338 A1, 2006 ;
Location in patent: Page/Page column 50 ;
WO 2006/034338 A1
反应条件
triethylamine in tetrahydrofuran; water T=0 - 20°C;
参考文献
Schering Corporation
Patent: US2004/266810 A1, 2004 ;
Location in patent: Page/Page column 6 ;
反应条件
1: piperidin-4-one hydrochloride With sodium hydroxide in water T=0°C; 2: carbamic acid 1,1-dimethylethyl ester in water 4 h;
参考文献
PIRAMAL LIFE SCIENCES LIMITED; SIVAKUMAR, Meenakshi; JOSHI, Kalpana Sanjay; AWARE, Valmik Sopan; SARDE, Ankush Gangaram; BAGUL, Sandeep Mukunda; MANOHAR, Sonal Mohan
Patent: WO2011/104680 A1, 2011 ;
Location in patent: Page/Page column 73 ;
WO 2011/104680 A1
反应条件
triethylamine in methanol T=20°C; 2 h;
参考文献
Hoffmann-La Roche Inc.; Hermann, Johannes Cornelius; Kuglstatter, Andreas; Lucas, Matthew C.; Padilla, Fernando; Wanner, Jutta; Zhang, Xiaohu
Patent: US2013/109661 A1, 2013 ;
Location in patent: Paragraph 0613-0614 ;
反应条件
PMHS; palladium dihydroxide in ethanol T=20°C; 5 h;
参考文献
Chandrasekhar; Babu, B. Nagendra; Reddy, Ch. Raji
Tetrahedron Letters, 2003 , vol. 44, # 10 p. 2057 - 2059
反应条件
1: CH2Cl2 / 1 h / 20 °C 2: tetrapropylammoniumperruthenate; NMO; 3 Angstroem molecular sieves / CH2Cl2 / 1 h View Scheme
参考文献
Bioorganic and medicinal chemistry letters, , vol. 12, # 13 p. 1785 - 1789
反应条件
hydrogen; platinum on activated charcoal in ethanol Ambient temperature;
参考文献
Moreno-Manas, Marcial; Perez, Montserrat; Pleixats, Roser
Tetrahedron, 1991 , vol. 50, # 2 p. 515 - 528
