N-叔丁氧羰基-4-哌啶酮合成路线

183673-70-32,4-二氧代-1,3,8-三氮杂螺[4,5]癸烷-8-甲酸叔丁酯

参考文献

Vachal, Petr; Miao, Shouwu; Pierce, Joan M.; Guiadeen, Deodial; Colandrea, Vincent J.; Wyvratt, Matthew J.; Salowe, Scott P.; Sonatore, Lisa M.; Milligan, James A.; Hajdu, Richard; Gollapudi, Anantha; Keohane, Carol A.; Lingham, Russell B.; Mandala, Suzanne M.; Demartino, Julie A.; Tong, Xinchun; Wolff, Michael; Steinhuebel, Dietrich; Kieczykowski, Gerard R.; Fleitz, Fred J.; Chapman, Kevin; Athanasopoulos, John; Adam, Gregory; Akyuz, Can D.; Jena, Dhirendra K.; Lusen, Jeffrey W.; Meng, Juncai; Stein, Benjamin D.; Xia, Lei; Sherer, Edward C.; Hale, Jeffrey J.
Journal of Medicinal Chemistry, 2012 , vol. 55, # 7 p. 2945 - 2959

183673-70-32,4-二氧代-1,3,8-三氮杂螺[4,5]癸烷-8-甲酸叔丁酯

参考文献

EISAI RandD MANAGEMENT CO., LTD.; SPYVEE, Mark; CHEN, Qian; CARLSON, Eric; KUSANO, Kuzutomi
Patent: WO2011/11494 A1, 2011 ;
Location in patent: Page/Page column 23-24 ;
WO 2011/011494 A1

151-50-8氰化钾+

79099-07-3N-叔丁氧羰基-4-哌啶酮

183673-70-32,4-二氧代-1,3,8-三氮杂螺[4,5]癸烷-8-甲酸叔丁酯

参考文献

ILDONG PHARMACEUTICAL CO., LTD
Patent: WO2008/150089 A1, 2008 ;
Location in patent: Page/Page column 14 ;
WO 2008/150089 A1

143-33-9氰化钠+

79099-07-3N-叔丁氧羰基-4-哌啶酮

183673-70-32,4-二氧代-1,3,8-三氮杂螺[4,5]癸烷-8-甲酸叔丁酯

参考文献

Gallagher, Brian M.; Carlson, Eric; Chen, Qian; Davis, Heather; Schiller, Shawn; Shaffer, Christina; Spyvee, Mark; Wong, Nancy
Patent: US2006/270696 A1, 2006 ;
Location in patent: Page/Page column 10 ;

506-87-6碳酸铵+

79099-07-3N-叔丁氧羰基-4-哌啶酮

183673-70-32,4-二氧代-1,3,8-三氮杂螺[4,5]癸烷-8-甲酸叔丁酯

参考文献

MERCK SHARP and DOHME CORP.; PIERCE, Joan, M.; HALE, Jeffrey, J.; MIAO, Shouwu; VACHAL, Petr
Patent: WO2010/147776 A1, 2010 ;
Location in patent: Page/Page column 35 ;

79099-07-3N-叔丁氧羰基-4-哌啶酮

183673-70-32,4-二氧代-1,3,8-三氮杂螺[4,5]癸烷-8-甲酸叔丁酯

参考文献

Hoechst Aktiengesellschaft; Genetech, Inc.
Patent: US6218415 B1, 2001 ;

143-33-9氰化钠+

506-87-6碳酸铵+

79099-07-3N-叔丁氧羰基-4-哌啶酮

183673-70-32,4-二氧代-1,3,8-三氮杂螺[4,5]癸烷-8-甲酸叔丁酯

参考文献

Wysong, Christopher L.; Yokum, T. Scott; Morales, Guillermo A.; Gundry, Rebekah L.; McLaughlin, Mark L.; Hammer, Robert P.
Journal of Organic Chemistry, 1996 , vol. 61, # 22 p. 7650 - 7651

7298-67-12-羟基-5-乙酰氨基苯乙酮+

79099-07-3N-叔丁氧羰基-4-哌啶酮

223559-44-26-乙酰基氨基-4-氧代-2-螺(n-boc-哌啶-4-基)-苯并吡喃

参考文献

Bioorganic and Medicinal Chemistry Letters, , vol. 9, # 2 p. 291 - 294

79099-07-3N-叔丁氧羰基-4-哌啶酮

211108-50-83-氟-4-氧代哌啶-1-甲酸叔丁酯

参考文献

Van Niel, Monique B.; Collins, Ian; Beer, Margaret S.; Broughton, Howard B.; Cheng, Susan K. F.; Goodacre, Simon C.; Heald, Anne; Locker, Karen L.; MacLeod, Angus M.; Morrison, Denise; Moyes, Christopher R.; O'Connor, Desmond; Pike, Andrew; Rowley, Michael; Russell, Michael G. N.; Sohal, Baibinder; Stanton, Josephine A.; Thomas, Steven; Verrier, Hugh; Watt, Alan P.; Castro, Jose L.
Journal of Medicinal Chemistry, 1999 , vol. 42, # 12 p. 2087 - 2104

79099-07-3N-叔丁氧羰基-4-哌啶酮

781649-87-44-(2-氧代-2,3-二氢-1H-咪唑并[4,5-b]吡啶-1-基)哌啶-1-羧酸叔丁酯

参考文献

Leahy, David K.; Desai, Lopa V.; Deshpande, Rajendra P.; Mariadass, Antony V.; Rangaswamy, Sundaramurthy; Rajagopal, Santhosh K.; Madhavan, Lakshmi; Illendula, Shashidhar
Organic Process Research and Development, 2012 , vol. 16, # 2 p. 244 - 249