N-叔丁氧羰基-4-哌啶酮合成路线 （共 500 条）
反应条件
sodium hydroxide; sodium tris(acetoxy)borohydride; acetic acid in dichloromethane
参考文献
Baxter, Ellen W.; Reitz, Allen B.
Patent: US2004/82612 A1, 2004 ;
US 20040082612 A1
反应条件
2: DMAP / tetrahydrofuran View Scheme
参考文献
Wysong, Christopher L.; Yokum, T. Scott; Morales, Guillermo A.; Gundry, Rebekah L.; McLaughlin, Mark L.; Hammer, Robert P.
Journal of Organic Chemistry, 1996 , vol. 61, # 22 p. 7650 - 7651
反应条件
t-BuOK; tert.-butyl lithium 1.) pentane, THF, a) -70 deg, 0.5 h, b) -20 deg, 2.5 h, 2.) THF, a) from -70 deg to RT, 4 h, b) RT, 16 h; Yield given. Multistep reaction;
参考文献
Nitta, Aiko; Iura, Yosuke; Inoue, Hideki; Imaoka, Takayuki; Takahashi, Toshiya; Sato, Ippei; Morihira, Koichiro; Kubota, Hirokazu; Morokata, Tatsuaki; Takeuchi, Makoto; Ohta, Mitsuaki; Tsukamoto, Shin-Ichi
Bioorganic and Medicinal Chemistry Letters, 2012 , vol. 22, # 22 p. 6876 - 6881,6
参考文献
Kowa Co., Ltd.
Patent: US6867221 B2, 2005 ;
参考文献
Kowa Co., Ltd.
Patent: US6867221 B2, 2005 ;
参考文献
Kowa Co., Ltd.
Patent: US6867221 B2, 2005 ;
反应条件
pyrrolidine in methanol T=60 - 65°C; 3 h;
参考文献
Solvay Pharmaceuticalss GmbH
Patent: US2007/117823 A1, 2007 ;
Location in patent: Page/Page column 13 ;
反应条件
1: 5'-bromo-2'-hydroxyacetophenone With pyrrolidine in methanol 2: tert-butyl 4-oxo-piperidine-1-carboxylate in methanol T=80°C;
参考文献
CEPHALON, INC.; PHARMACOPEIA, INC.
Patent: WO2009/97567 A1, 2009 ;
Location in patent: Page/Page column 62 ;
WO 2009/097567 A1
反应条件
1.1: n-butyllithium / tetrahydrofuran; hexane / 0.5 h / -78 °C 1.2: 2 h / 20 °C 1.3: 15 h / -78 - 20 °C 2.1: palladium on activated charcoal; hydrogen / methanol / 15 h / 20 °C 3.1: trifluoroacetic acid / dichloromethane / 5 h / 0 - 20 °C View Scheme
参考文献
Lee, Ju-Hyeon; Seo, Seon Hee; Lim, Eun Jeong; Cho, Nam-Chul; Nam, Ghilsoo; Kang, Soon Bang; Pae, Ae Nim; Jeong, Nakcheol; Keum, Gyochang
European Journal of Medicinal Chemistry, 2014 , vol. 74, p. 246 - 257
反应条件
1.1: n-butyllithium / hexane; diethyl ether / 1.5 h / -10 - 5 °C 1.2: 2 h / -20 - 20 °C 2.1: chloroform / Inert atmosphere 2.2: 4 - 50 °C 2.3: 1.5 h / Cooling with ice 3.1: sodium tetrahydroborate / ethanol / 12.5 h / 20 °C / Inert atmosphere 3.2: 4 - 50 °C View Scheme
参考文献
INTERVET INTERNATIONAL B.V.; LUTZ, Juergen; KOCH, Sandra; UPHOFF, Manfred; HECKEROTH, Anja Regina; OEPEN von, Britta; SONDERN, Ulrich
Patent: WO2011/95581 A1, 2011 ;
