N-叔丁氧羰基-4-哌啶酮合成路线 （共 500 条）
反应条件
trifluoroacetic acid in dichloromethane T=20°C; 20.5 h;
参考文献
Pike, Victor W.; Rash, Karen S.; Chen, Zhaogen; Pedregal, Concepcion; Statnick, Michael A.; Kimura, Yasuyuki; Hong, Jinsoo; Zoghbi, Sami S.; Fujita, Masahiro; Toledo, Miguel A.; Diaz, Nuria; Gackenheimer, Susan L.; Tauscher, Johannes T.; Barth, Vanessa N.; Innis, Robert B.
Journal of Medicinal Chemistry, 2011 , vol. 54, # 8 p. 2687 - 2700
反应条件
Amberlyst-15 in acetonitrile T=20°C; 0.0333333 h; IrradiationGreen chemistry;
参考文献
Rambabu; Kiran Kumar; Yogi Sreenivas; Sandra, Sandhya; Kandale, Ajit; Misra, Parimal; Basaveswara Rao; Pal, Manojit
Tetrahedron Letters, 2013 , vol. 54, # 6 p. 495 - 501
反应条件
1: With sodium tris(acetoxy)borohydride in 1,2-dichloro-ethane 18 h; 2: With ammonium acetate in dimethyl sulfoxide T=140°C; 4 h;
参考文献
BOEHRINGER INGELHEIM INTERNATIONAL GMBH
Patent: US2010/261714 A1, 2010 ;
Location in patent: Page/Page column 74 ;
反应条件
ammonium chloride; diisopropylamine in tetrahydrofuran; ethyl acetate
参考文献
SUNSHINE LAKE PHARMA CO., LTD.; ZHANG, Jiancun; ZHANG, Yingjun; ZHANG, Weihong; LIU, Bing; ZHANG, Jiquan; LIU, Jinlei; ZHANG, Lu
Patent: WO2013/71697 A1, 2013 ;
Location in patent: Paragraph 00305 ;
反应条件
1: tert-butyl 4-oxo-piperidine-1-carboxylate With pyrrolidine in toluene 3 h; Inert atmosphereReflux; 2: acetic anhydride in 1,4-dioxane; toluene T=20°C; Inert atmosphere; 3: With water in 1,4-dioxane; toluene 1 h; Reflux; Product distribution / selectivity;
参考文献
GLAXO GROUP LIMITED; BAILEY, James, Matthew; BROWN, John, Alexander; DEMONT, Emmanuel, Hubert; SEAL, Gail, Astra, Lorraine; SMETHURST, Christian, Alan, Paul; WITHERINGTON, Jason; HARRISON, Lee, Andrew
Patent: WO2010/146104 A1, 2010 ;
Location in patent: Page/Page column 28-29 ;
WO 2010/146104 A1
反应条件
sodium hydride in tetrahydrofuran; toluene T=40°C; 6 h;
参考文献
Wang, Pu-Sheng; Zhou, Xiao-Le; Gong, Liu-Zhu
Organic Letters, 2014 , vol. 16, # 3 p. 976 - 979
反应条件
1.1: toluene-4-sulfonic acid / toluene / |Dean-Stark; |Inert atmosphere; |Reflux 2.1: triethylamine / dichloromethane / 3 h / 0 °C / |Inert atmosphere 2.2: 1 h / |Inert atmosphere View Scheme
参考文献
Yogeeswari, Perumal; Sharma, Monika; Samala, Ganesh; Gangadhar, Matharasala; Karthick, Srirama; Mallipeddi, Saketh; Semwal, Arvind; Sriram, Dharmarajan
European Journal of Medicinal Chemistry, 2013 , vol. 66, p. 211 - 220
反应条件
1.1: sodium hydride / mineral oil; tetrahydrofuran / 0.5 h / 20 °C / |Inert atmosphere 1.2: 8 h / 20 °C 2.1: palladium on activated charcoal; hydrogen / ethanol / 5 h / 20 °C 3.1: diisobutylaluminium hydride / dichloromethane; hexane / 3 h / -78 °C 4.1: 4-(N,N-dimethylamino)benzoic acid; pyrrolidine / dichloromethane / |Reflux; |Inert atmosphere 5.1: sodium tetrahydroborate / methanol / 2 h / 0 °C View Scheme
参考文献
Zhao, Yi; Jiang, Xiaojian; Yeung, Ying-Yeung
Angewandte Chemie - International Edition, 2013 , vol. 52, # 33 p. 8597 - 8601
Angew. Chem., 2013 , vol. 125, # 33 p. 8759 - 8763,5
反应条件
potassium hydroxide in methanol T=60°C; 18 h; Product distribution / selectivity;
参考文献
MYREXIS, INC.; KUMAR, Dange Vijay; SLATTUM, Paul M.; YAGER, Kraig M.; SHENDEROVICH, Mark D.; TANGALLAPALLY, Rajendra; KIM, Se-Ho
Patent: WO2012/177782 A1, 2012 ;
Location in patent: Page/Page column 70 ;
WO 2012/177782 A1
反应条件
1.1: N-ethyl-N,N-diisopropylamine; n-butyllithium / hexane; tetrahydrofuran / 0.5 h / -78 °C / |Inert atmosphere 1.2: -78 - 20 °C / |Inert atmosphere 2.1: tetrakis(triphenylphosphine) palladium(0) / ethylene glycol dimethyl ether / 0.33 h / 80 °C / |Inert atmosphere; |Microwave irradiation 3.1: trifluoroacetic acid / dichloromethane / 0.5 h / 20 °C View Scheme
参考文献
JANSSEN RandD IRELAND; GUILLEMONT, Jerôme Emile Georges; LANÇOIS, David Francis Alain; MOTTE, Magali Madeleine Simone; BALEMANS, Wendy Mia Albert; KOUL, Anil
Patent: WO2014/23815 A1, 2014 ;
