N-叔丁氧羰基-4-哌啶酮合成路线 （共 500 条）
反应条件
water; triethylamine in dichloromethane T=-30°C; 1 h;
参考文献
GLAXO GROUP LIMITED
Patent: WO2004/5256 A2, 2004 ;
Location in patent: Page 43-44 ;
WO 2004/005256 A2
反应条件
lithium hexamethyldisilazane in tetrahydrofuran; ethyl acetate
参考文献
Jana, Navendu; Nguyen, Quyen; Driver, Tom G.
Journal of Organic Chemistry, 2014 , vol. 79, # 6 p. 2781 - 2791
反应条件
1: tert-butyl 4-oxo-piperidine-1-carboxylate With lithium diisopropyl amide in tetrahydrofuran 0.5 h; 2: Tf2NPh in tetrahydrofuran T=20°C;
参考文献
Merck and Co., Inc.
Patent: US6235759 B1, 2001 ;
US 6235759 B1
反应条件
1: tert-butyl 4-oxo-piperidine-1-carboxylate With n-butyllithium; diisopropylamine in tetrahydrofuran; hexane T=-78°C; 2 h; 2: PhN(OTf)2 in tetrahydrofuran; hexane T=-78°C; Cooling;
参考文献
Okitsu, Takashi; Iwatsuka, Kinya; Wada, Akimori
Chemical Communications, 2008 , # 47 p. 6330 - 6332
反应条件
in tetrahydrofuran; ethyl acetate
参考文献
Salon, John A.; Laz, Thomas M.; Nagorny, Raisa; Wilson, Amy E.; Craig, Douglas A.
Patent: US2004/38855 A1, 2004 ;
反应条件
in tetrahydrofuran; hexane; ethyl acetate
参考文献
Cai, Guolin; Chau, Jennifer N.; Dominguez, Celia; Lu, Yuelie; Rishton, Gilbert M.
Patent: US2003/195221 A1, 2003 ;
反应条件
pyridinium p-toluenesulfonate in benzene 8 h; Reflux;
参考文献
Chemistry of Natural Compounds, , vol. 46, # 2 p. 254 - 256
反应条件
toluene-4-sulfonic acid in toluene 72 h; RefluxInert atmosphere;
参考文献
Organic Letters, , vol. 12, # 18 p. 4176 - 4179
反应条件
NaH; palladium monocarbide in tetrahydrofuran; ethanol; water; ethyl acetate
参考文献
Sumitomo Pharmaceuticals Company, Limited
Patent: US5707994 A1, 1998 ;
反应条件
1: NaH / tetrahydrofuran / 0 °C 2: H2 / Pd/C / methanol / 20 °C View Scheme
参考文献
Sato, Tatsunori; Okamoto, Kazuya; Nakano, Yuko; Uenishi, Jun'ichi; Ikeda, Masazumi
Heterocycles, 2001 , vol. 54, # 2 p. 747 - 755
