N-叔丁氧羰基-4-哌啶酮合成路线 （共 500 条）
反应条件
sodium hydride in dimethyl sulfoxide
参考文献
GLAXO GROUP LIMITED
Patent: WO2008/129007 A1, 2008 ;
Location in patent: Page/Page column 38 ;
WO 2008/129007 A1
反应条件
1: trimethyl-sulfonium iodide With sodium hydride in dimethyl sulfoxide T=5°C; 0.5 h; 2: tert-butyl 4-oxo-piperidine-1-carboxylate in dimethyl sulfoxide T=20°C; 1 h;
参考文献
ASTRAZENECA AB; ASTRAZENECA UK LIMITED
Patent: WO2005/79805 A1, 2005 ;
Location in patent: Page/Page column 72 ;
WO 2005/079805 A1
反应条件
potassium hydroxide in acetonitrile T=20°C; 48 h;
参考文献
SOLVAY PHARMACEUTICALS GmbH.
Patent: US2005/131004 A1, 2005 ;
Location in patent: Page/Page column 10-11 ;
US 20050131004 A1
反应条件
in dimethyl sulfoxide T=55°C; 6 h;
参考文献
AGOURON PHARMACEUTICALS, INC.
Patent: US2006/46991 A1, 2006 ;
Location in patent: Page/Page column 59-60 ;
US 20060046991 A1
反应条件
1: trimethyl sulfoxonium iodide With sodium hydride in dimethyl sulfoxide T=5 - 20°C; 1 h; 2: tert-butyl 4-oxo-piperidine-1-carboxylate in dimethyl sulfoxide T=5 - 50°C; 1.5 h;
参考文献
TAKEDA PHARMACEUTICAL COMPANY LIMITED
Patent: WO2005/118587 A1, 2005 ;
Location in patent: Page/Page column 223-224 ;
WO 2005/118587 A1
反应条件
in dimethyl sulfoxide T=50°C; 2 h;
参考文献
MERCK and CO., INC.
Patent: WO2004/58763 A1, 2004 ;
Location in patent: Page 31 ;
WO 2004/058763 A1
反应条件
1: tert-butyl 4-oxo-piperidine-1-carboxylate With trichlorophosphate; N,N-dimethyl-formamide in dichloromethane T=0 - 20°C; 2: mercapto acetic acid ethylester With triethylamine in dichloromethane T=20°C; 3.5 h; Reflux;
参考文献
SYNTARGA B.V.; BEUSKER, Patrick Henry; COUMANS, Rudy Gerardus Elisabeth; ELGERSMA, Ronald Christiaan; MENGE, Wiro Michael Petrus Bernardus; JOOSTEN, Johannes Albertus Frederikus; SPIJKER, Henri Johannes; DE GROOT, Franciscus Marinus Hendrikus
Patent: WO2010/62171 A2, 2010 ;
Location in patent: Page/Page column 158 ;
反应条件
1: in dichloromethane T=20°C; 1 h; 2: With sodium tris(acetoxy)borohydride in dichloromethane T=20°C; 24 h;
参考文献
Yang, Shyh-Ming; Tang, Yuting; Rano, Thomas; Lu, Huajun; Kuo, Gee-Hong; Gaul, Michael D.; Li, Yaxin; Ho, George; Lang, Wensheng; Conway, James G.; Liang, Yin; Lenhard, James M.; Demarest, Keith T.; Murray, William V.
Bioorganic and Medicinal Chemistry Letters, 2014 , vol. 24, # 5 p. 1437 - 1441
反应条件
sodium tris(acetoxy)borohydride in acetic acid T=50°C; 18 h;
参考文献
Faul, Margaret M.; Grutsch, John L.; Kobierski, Michael E.; Kopach, Michael E.; Krumrich, Christine A.; Staszak, Michael A.; Udodong, Uko; Vicenzi, Jeffrey T.; Sullivan, Kevin A.
Tetrahedron, 2003 , vol. 59, # 36 p. 7215 - 7229
反应条件
1: 99 percent / NaBH(OAc)3 / acetic acid / 1 h / 20 °C 2: 88 percent / DDQ / tetrahydrofuran / 0.75 h / 0 - 5 °C View Scheme
参考文献
Faul, Margaret M.; Grutsch, John L.; Kobierski, Michael E.; Kopach, Michael E.; Krumrich, Christine A.; Staszak, Michael A.; Udodong, Uko; Vicenzi, Jeffrey T.; Sullivan, Kevin A.
Tetrahedron, 2003 , vol. 59, # 36 p. 7215 - 7229
