N-叔丁氧羰基-4-哌啶酮合成路线 （共 500 条）
反应条件
diisopropylamine in tetrahydrofuran; hexane; ethyl acetate
参考文献
Merck and Co., Inc.
Patent: US6265434 B1, 2001 ;
US 6265434 B1
反应条件
1: lithium hexamethyldisilazane / tetrahydrofuran / -10 °C 2: Acidic conditions; Heating View Scheme
参考文献
Calvo, Raul R.; Meegalla, Sanath K.; Parks, Daniel J.; Parsons, William H.; Ballentine, Shelley K.; Lubin, Mary Lou; Schneider, Craig; Colburn, Raymond W.; Flores, Christopher M.; Player, Mark R.
Bioorganic and Medicinal Chemistry Letters, 2012 , vol. 22, # 5 p. 1903 - 1907
反应条件
sodium hydroxide; n-butyllithium; palladium monocarbide in tetrahydrofuran; methanol; ethanol; hexane; water; ethyl acetate
参考文献
Sumitomo Pharmaceuticals Company, Limited
Patent: US5707994 A1, 1998 ;
反应条件
hydrogenchloride; lithium hydroxide; hydrogen; potassium hexamethylsilazane; palladium in tetrahydrofuran; water; ethyl acetate; toluene
参考文献
Merck and Co., Inc.
Patent: US6399619 B1, 2002 ;
US 6399619 B1
反应条件
1: toluene / 95 - 105 °C 2: H2 / 10 percent Pd/C / ethanol 3: NaOH / tetrahydrofuran; H2O; methanol View Scheme
参考文献
Dener, Jeffrey M.; Rice, Kenneth D.; Newcomb, William S.; Wang, Vivian R.; Young, Wendy B.; Gangloff, Anthony R.; Kuo, Elaine Y.-L.; Cregar, Lynne; Putnam, Daun; Wong, Martin
Bioorganic and Medicinal Chemistry Letters, 2001 , vol. 11, # 13 p. 1629 - 1633
反应条件
1: With potassium tert-butylate in N,N-dimethyl-formamide T=-50 - -40°C; Julia-Kocienski type gem-difluoroolefination; 0.25 h; Inert atmosphere; 2: With hydrogenchloride; water; ammonium chloride in N,N-dimethyl-formamide T=-40 - 20°C; Inert atmosphere;
参考文献
Zhao, Yanchuan; Huang, Weizhou; Zhu, Lingui; Hu, Jinbo
Organic Letters, 2010 , vol. 12, # 7 p. 1444 - 1447
反应条件
1: carbonic acid dimethyl ester With sodium hydride in toluene T=20°C; 0.5 h; Inert atmosphere; 2: tert-butyl 4-oxo-piperidine-1-carboxylate in toluene T=80°C; 3.58333 h; Inert atmosphere; 3: With acetic acid in toluene T=0°C; pH=6 - 6.5;
参考文献
Chai, Yun; Wan, Zhi-Long; Wang, Bo; Guo, Hui-Yuan; Liu, Ming-Liang
European Journal of Medicinal Chemistry, 2009 , vol. 44, # 10 p. 4063 - 4069
反应条件
1: Methyltriphenylphosphonium bromide With n-butyllithium in tetrahydrofuran T=-78°C; 1 h; 2: tert-butyl 4-oxo-piperidine-1-carboxylate in tetrahydrofuran T=-78 - 20°C;
参考文献
ASTRAZENECA AB; NPS PHARMACEUTICALS, INC.
Patent: WO2006/20879 A1, 2006 ;
Location in patent: Page/Page column 101-102 ;
WO 2006/020879 A1
反应条件
1: Methyltriphenylphosphonium bromide With potassium tert-butylate in diethyl ether T=0°C; 2 h; Inert atmosphere; 2: tert-butyl 4-oxo-piperidine-1-carboxylate in diethyl ether T=0 - 20°C; 17 h; Cooling with ice;
参考文献
BETA PHARMA CANADA INC.; WANG, Zhaoyin; LI, Lianhai; WANG, Zhigang
Patent: WO2013/13308 A1, 2013 ;
Location in patent: Paragraph 00196-00198 ;
WO 2013/013308 A1
反应条件
1: triphenyl-methyl-phosphonium iodide With n-butyllithium in tetrahydrofuran; hexane T=0°C; 1 h; 2: tert-butyl 4-oxo-piperidine-1-carboxylate in tetrahydrofuran; hexane T=0 - 20°C;
参考文献
XENON PHARMACEUTICALS INC.
Patent: WO2006/34338 A1, 2006 ;
Location in patent: Page/Page column 50 ;
WO 2006/034338 A1
