N-叔丁氧羰基-4-哌啶酮合成路线 （共 500 条）
反应条件
caesium carbonate in tetrahydrofuran; N,N-dimethyl-formamide T=70°C; 16 h;
参考文献
Aissa, Christophe
Journal of Organic Chemistry, 2006 , vol. 71, # 1 p. 360 - 363
反应条件
potassium tert-butylate in diethyl ether
参考文献
Gruenenthal GmbH
Patent: US2008/269271 A1, 2008 ;
反应条件
in tetrahydrofuran; diethyl ether
参考文献
Eisai Co., Ltd.
Patent: US6498159 B1, 2002 ;
反应条件
1.1: acetic acid / toluene / 6 h / Heating 1.2: NaBH3CN; acetic acid / toluene; tetrahydrofuran / 24 h / 20 °C 2.1: N,N-diisopropylethylamine / tetrahydrofuran / 73 h / 0 - 20 °C View Scheme
参考文献
Williams, Peter D.; Clineschmidt, Bradley V.; Erb, Jill M.; Freidinger, Roger M.; Guidotti, Maribeth T.; et al.
Journal of Medicinal Chemistry, 1995 , vol. 38, # 23 p. 4634 - 4636
反应条件
1: Reflux 2: methanol / 3 h / Reflux View Scheme
参考文献
SANOFI
Patent: US2012/245149 A1, 2012 ;
反应条件
1.1: lithium diisopropyl amide / n-heptane; tetrahydrofuran; ethylbenzene / 0.5 h / -78 °C 1.2: 24.5 h / -78 - 20 °C 2.1: sodium carbonate; lithium chloride / tetrakis(triphenylphosphine) palladium(0) / 1,4-dioxane / 4 h / 85 - 90 °C 3.1: hydrogen / palladium 10 on activated carbon / N,N-dimethyl-formamide; ethanol / 24 h / 20 °C View Scheme
参考文献
AFRAXIS, INC.; CAMPBELL, David; DURÓN, Sergio, G.
Patent: WO2013/43232 A2, 2013 ;
WO 2013/043232 A2
反应条件
1.1: 99 percent / NaBH(OAc)3 / acetic acid / 1 h / 20 °C 2.1: 88 percent / DDQ / tetrahydrofuran / 0.75 h / 0 - 5 °C 3.1: 70 percent / TFA / ethyl acetate / 12 h / 60 °C 4.1: 97 percent / K2CO3 / dimethylformamide / 5 h / 20 - 50 °C 5.1: HCl gas / acetonitrile / 0.5 h / 0 - 20 °C 5.2: acetonitrile / 2 h / -10 - 0 °C 5.3: 86.5 percent / acetonitrile / 1 h / -10 - 0 °C 6.1: 75 percent / t-BuOK / tetrahydrofuran / -5 - 45 °C View Scheme
参考文献
Faul, Margaret M.; Grutsch, John L.; Kobierski, Michael E.; Kopach, Michael E.; Krumrich, Christine A.; Staszak, Michael A.; Udodong, Uko; Vicenzi, Jeffrey T.; Sullivan, Kevin A.
Tetrahedron, 2003 , vol. 59, # 36 p. 7215 - 7229
反应条件
diisopropylamine in tetrahydrofuran; tris(1-aziridinyl)phosphine oxide; hexane; ethyl acetate; tert-butyl alcohol
参考文献
Merck and Co., Inc.
Patent: US6013652 A1, 2000 ;
US 6013652 A
反应条件
1: lithium diisopropyl amide / tetrahydrofuran / 18 h / -75 - 23 °C 2: potassium tert-butylate / tert-butyl alcohol / 2 h / 20 - 35 °C View Scheme
参考文献
AURIGENE DISCOVERY TECHNOLOGIES LIMITED; TAKHI, Mohamed; HOSAHALLI, Subramanya; PANIGRAHI, Sunil Kumar; MAHADARI, Muni Kumar; KOTTAM, Chandrashekar Reddy; ABD RAHMAN, Noorsaadah; YUSOF, Rohana
Patent: WO2013/80222 A1, 2013 ;
反应条件
1.1: Ti(O-iPr)4 1.2: NaBH3CN 2.1: CF3CO2H View Scheme
参考文献
Boursereau, Yohan; Coldham, Iain
Bioorganic and Medicinal Chemistry Letters, 2004 , vol. 14, # 23 p. 5841 - 5844
