N-叔丁氧羰基-4-哌啶酮合成路线 （共 500 条）
反应条件
sodium tetrahydroborate in ethanol
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 11, # 7 p. 891 - 894
反应条件
1: C18H26BrN3O4 With trifluoroacetic acid in dichloromethane 0.5 h; 2: C13H18BrN3O2; tert-butyl 4-oxo-piperidine-1-carboxylate With sodium tris(acetoxy)borohydride; triethylamine in 1,2-dichloro-ethane T=20°C; 16 h; 3: With water; sodium hydrogencarbonate in dichloromethane; 1,2-dichloro-ethane
参考文献
WO2008/8453 A1, ;
Page/Page column 66 ;
WO 2008/008453 A1
反应条件
sodium cyanoborohydride; acetic acid in methanol T=60°C; 16 h;
参考文献
WO2008/70758 A1, ;
Page/Page column 31 ;
WO 2008/070758 A1
反应条件
diisobutylaluminium hydride in tetrahydrofuran; toluene
反应条件
sodium cyanoborohydride in methanol
参考文献
US6051572 A1, ;
US 6051572 A
反应条件
N,N,N',N',N'',N''-hexamethylphosphoric triamide; samarium diiodide; tert-butyl alcohol in tetrahydrofuran T=20°C; Title compound not separated from byproducts;
参考文献
Chemistry - A European Journal, , vol. 10, # 21 p. 5493 - 5506
反应条件
sodium tris(acetoxy)borohydride in dichloromethane T=20°C; 2 h; Inert atmosphere;
参考文献
ChemMedChem, , vol. 6, # 4 p. 654 - 666
反应条件
sodium hydroxide; sodium tris(acetoxy)borohydride; acetic acid; aniline in diethyl ether; dichloromethane
参考文献
Tsushima, Masaki; Tadauchi, Kaori; Asai, Kenji; Miike, Naoko; Imai, Masako; Kudo, Toshiaki
Patent: US2003/171370 A1, 2003 ;
US 20030171370 A1
反应条件
1: AcOH / toluene / 6 h / Heating 2: NaCNBH3, AcOH / toluene; tetrahydrofuran / 24 h / Ambient temperature View Scheme
参考文献
Williams, Peter D.; Clineschmidt, Bradley V.; Erb, Jill M.; Freidinger, Roger M.; Guidotti, Maribeth T.; et al.
Journal of Medicinal Chemistry, 1995 , vol. 38, # 23 p. 4634 - 4636
