N-叔丁氧羰基-4-哌啶酮合成路线 （共 500 条）
反应条件
1: sodium hydride / tetrahydrofuran / 20 °C 2: palladium 10 on activated carbon; hydrogen / ethanol 3: water; potassium hydroxide / ethanol / 20 °C View Scheme
参考文献
Wang, Xiao Jian; Xi, Mei Yang; Fu, Ji Hua; Zhang, Fu Rong; Cheng, Gui Fang; Yin, Da Li; You, Qi Dong
Chinese Chemical Letters, 2012 , vol. 23, # 6 p. 707 - 710
反应条件
1: NaH / tetrahydrofuran / 0 °C 2: H2 / Pd/C / methanol / 20 °C 3: LAH / tetrahydrofuran / 20 °C 4: NEt3 / tetrahydrofuran / 0 °C 5: NaN3 / dimethylformamide / 20 °C 6: H2 / Pd/C / methanol / 20 °C View Scheme
参考文献
Ogino, Yoshio; Ohtake, Norikazu; Kobayashi, Kensuke; Kimura, Toshifumi; Fujikawa, Toru; Hasegawa, Takuro; Noguchi, Kazuhito; Mase, Toshiaki
Bioorganic and Medicinal Chemistry Letters, 2003 , vol. 13, # 13 p. 2167 - 2172
反应条件
hydrazine monohydrochloride; hydrogen; platinum on carbon in methanol; water P=45603.1 Torr; 15 h; Inert atmosphereSealed autoclave;
参考文献
PFIZER INC.; MASCITTI, Vincent; MCCLURE, Kim Francis; MUNCHHOF, Michael John; ROBINSON, Ralph Pelton, Jr.
Patent: WO2012/69948 A1, 2012 ;
Location in patent: Page/Page column 54 ;
反应条件
1: lithium hexamethyldisilazane / tetrahydrofuran / 1 h / -78 - 20 °C / |Inert atmosphere 2: tetrahydrofuran / 15 h / -78 °C / |Inert atmosphere 3: bis-triphenylphosphine-palladium(II) chloride; sodium hydrogencarbonate / water; tetrahydrofuran / 1.5 h / 80 °C / |Inert atmosphere 4: Rh2(esp)2 / toluene / 16 h / 80 °C / |Inert atmosphere View Scheme
参考文献
Jana, Navendu; Nguyen, Quyen; Driver, Tom G.
Journal of Organic Chemistry, 2014 , vol. 79, # 6 p. 2781 - 2791
反应条件
1: piperazine-1-carboxylic acid benzyl ester; tert-butyl 4-oxo-piperidine-1-carboxylate With hydrogen; acetic acid; palladium 10 on activated carbon in methanol 96 h; 2: benzyl chloroformate With sodium hydrogencarbonate in water; acetone T=0°C; 3.5 h;
参考文献
Eisai RandD Management Co., Ltd.
Patent: EP1889836 A1, 2008 ;
Location in patent: Page/Page column 78 ;
反应条件
1: With acetic acid in 1,2-dichloro-ethane T=20°C; 1 h; 2: With sodium tris(acetoxy)borohydride in 1,2-dichloro-ethane T=20°C; Inert atmosphere;
参考文献
Long, Daniel D.; McKinnell, Robert Murray; Van Orden, Lori Jean; Ogawa, Gavin; Wilton, Donna
Patent: US2013/287730 A1, 2013 ;
Location in patent: Paragraph 0280 ;
反应条件
1: With isopropylmagnesium chloride lithium chloride complex in tetrahydrofuran T=-50°C; 2: With methanol; acetic acid in tetrahydrofuran
参考文献
Kuethe, Jeffrey T.; Maloney, Kevin M.
Tetrahedron, 2013 , vol. 69, # 25 p. 5248 - 5258
反应条件
n-butyllithium T=-78 - 20°C; Reagent/catalyst;
参考文献
Kuethe, Jeffrey T.; Maloney, Kevin M.
Tetrahedron, 2013 , vol. 69, # 25 p. 5248 - 5258
参考文献
Tsushima, Masaki; Tadauchi, Kaori; Asai, Kenji; Miike, Naoko; Imai, Masako; Kudo, Toshiaki
Patent: US2003/171370 A1, 2003 ;
US 20030171370 A1
反应条件
NaCNBH3; acetic acid in ethyl acetate; toluene
参考文献
Merck and Co., Inc.
Patent: US5665719 A1, 1997 ;
US 5665719 A
