N-叔丁氧羰基-4-哌啶酮合成路线 （共 500 条）
反应条件
1: 61 percent / tetramethylguanidine / ethyl acetate / 42 h / 20 °C 2: H2 / [(R,R)-Me-BPE-Rh-COD]OTf / methanol / 72 h / 20 °C / 4654.33 Torr 3: 98 percent / 1N LiOH / methanol / 20 h / 20 °C 4: 82 percent / H2 / 5 percent Pd/C / ethanol; H2O / 16 h / 20 °C / 2585.74 Torr View Scheme
参考文献
Shieh, Wen-Chung; Xue, Song; Reel, Noela; Wu, Raeann; Fitt, John; Repic, Oljan
Tetrahedron Asymmetry, 2001 , vol. 12, # 17 p. 2421 - 2425
反应条件
1: in tetrahydrofuran T=-50°C; 1.5 h; 2: With ammonium chloride
参考文献
GALDERMA RESEARCH andamp; DEVELOPMENT; BOUIX-PETER, Claire; SUZUKI, Itaru; PELISSON, Isabelle; COLLETTE, Pascal; TABET, Samuel; LAFITTE, Guillaume
Patent: WO2010/52255 A1, 2010 ;
Location in patent: Page/Page column 57 ;
WO 2010/052255 A1
反应条件
1: C6H5Hal With magnesium in tetrahydrofuran 2: tert-butyl 4-oxo-piperidine-1-carboxylate in tetrahydrofuran
参考文献
Kumagai, Toshihito; Okubo, Taketoshi; Kataoka-Okubo, Hiromi; Chaki, Shigeyuki; Okuyama, Shigeru; Nakazato, Atsuro
Bioorganic and Medicinal Chemistry, 2001 , vol. 9, # 5 p. 1357 - 1363
参考文献
Chen, Jian Jeffrey; Dewdney, Nolan; Lin, Xiaohong; Martin, Robert L.; Walker, Keith A. M.; Huang, Jane; Chu, Frances; Eugui, Elsie; Mirkovich, Anna; Kim, Yong; Sarma, Keshab; Arzeno, Humberto; Van Wart, Harold E.
Bioorganic and Medicinal Chemistry Letters, 2003 , vol. 13, # 22 p. 3951 - 3954
反应条件
1: 94 percent / toluene / 12 h / Heating 2: 35 percent / 1,1,3,3-tetramethylguanidine / 10 h / Heating 3: 81 percent / Raney Ni / ethanol; H2O / 24 h / Ambient temperature 4: 99 percent / NaH / tetrahydrofuran / 12 h / Heating View Scheme
参考文献
Smith, Paul W.; Cooper, Anthony W. J.; Bell, Richard; Beresford, Isabel J. M.; Gore, Paul M.; et al.
Journal of Medicinal Chemistry, 1995 , vol. 38, # 19 p. 3772 - 3779
反应条件
NaBH(OAc)3 in dichloromethane
参考文献
Butler, Christopher R.; Cai, Hui; Edwards, James P.; Grice, Cheryl A.; Gu, Yin; Gustin, Darin J.; Karlsson, Lars; Khatuya, Haripada; Meduna, Steven P.; Pio, Barbara A.; Sehon, Clark A.; Sun, Siquan; Tays, Kevin L.; Thurmond, Robin L.; Wei, Jianmei
Patent: US2005/101587 A9, 2005 ;
反应条件
1: NaBH(OAc)3 / 1,2-dichloro-ethane / 20 °C 2: pyridine / tetrahydrofuran / 60 °C View Scheme
参考文献
Nerenberg, Jennie B.; Erb, Jill M.; Thompson, Wayne J.; Lee, Hee-Yoon; Guare, James P.; Munson, Peter M.; Bergman, Jeffrey M.; Huff, Joel R.; Broten, Theodore P.; Chang, Raymond S. L.; Chen, Tsing B.; O'Malley, Stacey; Schorn, Terry W.; Scott, Ann L.
Bioorganic and Medicinal Chemistry Letters, 1998 , vol. 8, # 18 p. 2467 - 2472
反应条件
1.1: n-BuLi / tetrahydrofuran / -78 °C 1.2: tetrahydrofuran / 1 h / -78 °C 2.1: H2 / Pd/C / ethanol 3.1: p-TsOH / toluene / 3 h / Heating 4.1: AcCl; MeOH / 16 h / 0 - 20 °C View Scheme
参考文献
Cooper, Laura C.; Carlson, Emma J.; Castro, Jose L.; Chicchi, Gary G.; Dinnell, Kevin; Di Salvo, Jerry; Elliott, Jason M.; Hollingworth, Gregory J.; Kurtz, Marc M.; Ridgill, Mark P.; Rycroft, Wayne; Tsao, Kwei-Lan; Swain, Christopher J.
Bioorganic and Medicinal Chemistry Letters, 2002 , vol. 12, # 13 p. 1759 - 1762
反应条件
1: lithium hexamethyldisilazane / tetrahydrofuran / 0.67 h / -70 °C / Inert atmosphere 2: hydrogen / palladium 10 on activated carbon / ethyl acetate / 3.5 h / 20 °C View Scheme
参考文献
DAIICHI SANKYO COMPANY, LIMITED
Patent: US2012/220609 A1, 2012 ;
反应条件
hydrogen; platinum on carbon in ethanol; water T=50°C; P=1500.15 Torr; 4 h;
参考文献
ASTRAZENECA AB; ASTRAZENECA UK LIMITED
Patent: WO2006/64221 A1, 2006 ;
Location in patent: Page/Page column 7 ;
WO 2006/064221 A1
