N-叔丁氧羰基-4-哌啶酮合成路线 （共 500 条）
反应条件
1: 93.2 percent / diazabicycloundecane / CH2Cl2 / 2 h / 20 °C 2: H2 / Pd/C / methanol / 12 h / 20 °C / 2327.23 Torr View Scheme
参考文献
Pikul; Ohler; Ciszewski; Laufersweiler; Almstead; De; Natchus; Hsieh; Janusz; Peng; Branch; King; Taiwo; Mieling
Journal of Medicinal Chemistry, 2001 , vol. 44, # 16 p. 2499 - 2502
参考文献
Merck Sharp and Dohme, Ltd.
Patent: US5854268 A1, 1998 ;
反应条件
1: 67 percent / NaBH(OAc)3 / acetic acid; CH2Cl2 / 3 h / 25 °C 2: 100 percent / NaHCO3 / ethyl acetate; H2O / 4 h / 25 °C View Scheme
参考文献
Tetrahedron Letters, , vol. 37, # 35 p. 6327 - 6330
反应条件
1: Sodium hydride / tetrahydrofuran / 2.67 h / 0 - 20 °C / Heating / reflux 2: hydrogen / palladium 10 on activated carbon / ethanol / 5 h / 2585.81 Torr View Scheme
参考文献
Walker, Daniel Patrick; Piotrowski, David W.; Jacobsen, Eric Jon; Acker, Brad A.; Myers, Jason K.; Groppi JR., Vincent E.
Patent: US2003/236279 A1, 2003 ;
反应条件
1: 1.) LDA, 2.) PhN(SO2CF3)2, 3.) Pd(PPh3)4, LiCl, aq. Na2CO3, 4.) H2 / 4.) Pd/C 2: HCl / methanol 3: CH2Cl2 View Scheme
参考文献
Elliott; Broughton; Cascieri; Chicchi; Huscroft; Kurtz; MacLeod; Sadowski; Stevenson
Bioorganic and Medicinal Chemistry Letters, 1998 , vol. 8, # 14 p. 1851 - 1856
反应条件
1: With ammonium chloride; zinc in tetrahydrofuran T=10°C; Industry scale; 2: With sulfuric acid; water in tetrahydrofuran pH=~ 6; Industry scale; 3: With sodium hydrogencarbonate in tetrahydrofuran; water; tert-butyl alcohol Industry scale;
参考文献
WO2010/58318 A1, ;
Page/Page column 25-26 ;
WO 2010/058318 A1
反应条件
in tetrahydrofuran; diethyl ether T=0 - 23°C; 18 h;
参考文献
Tetrahedron Letters, , vol. 52, # 48 p. 6457 - 6459
反应条件
zinc in tetrahydrofuran
参考文献
US6265434 B1, ;
US 6265434 B1
反应条件
in methanol; diethyl ether
