N-叔丁氧羰基-4-哌啶酮合成路线 （共 500 条）
反应条件
1: dimethyl methoxycarbonylmethanephosphonate With sodium hydride in N,N-dimethyl-formamide T=0°C; 0.333333 h; 2: tert-butyl 4-oxo-piperidine-1-carboxylate in N,N-dimethyl-formamide T=0 - 20°C; 3.33333 h;
参考文献
THE REGENTS OF THE UNIVERSITY OF MICHIGAN; THE CURATORS OF THE UNIVERSITY OF MISSOURI; GINSBURG, David; LARSEN, Scott D.; YESTREPSKY, Bryan; SUN, Hongmin
Patent: WO2013/166282 A2, 2013 ;
Location in patent: Page/Page column 95 ;
反应条件
in toluene T=20°C; Heating / reflux;
参考文献
Cumbre Inc.
Patent: US2006/19985 A1, 2006 ;
Location in patent: Page/Page column 55 ;
反应条件
1: dimethyl methoxycarbonylmethanephosphonate With sodium hydride in N,N-dimethyl-formamide T=0°C; 0.333333 h; 2: tert-butyl 4-oxo-piperidine-1-carboxylate in N,N-dimethyl-formamide T=20°C; 3 h;
参考文献
Bristol-Myers Squibb Company
Patent: US2007/259850 A1, 2007 ;
Location in patent: Page/Page column 79 ;
US 20070259850 A1
反应条件
hydrogenchloride; sodium hydrogencarbonate in tetrahydrofuran
参考文献
Daiichi Pharmaceutical Co., Ltd.
Patent: US6525042 B1, 2003 ;
反应条件
hydrogenchloride; sodium hydrogencarbonate in tetrahydrofuran
参考文献
DAIICHI PHARMACEUTICAL CO., LTD.
Patent: EP1104754 A1, 2001 ;
反应条件
1: diethyl methoxycarbonylmethyl-phosphonate With potassium hexamethylsilazane in tetrahydrofuran 2: tert-butyl 4-oxo-piperidine-1-carboxylate in tetrahydrofuran
参考文献
Chambers, Mark Stuart; Jones, Philip; Szekeres, Helen Jane
Patent: US2004/2504 A1, 2004 ;
Location in patent: Page/Page column 23-24; 26 ;
US 20040002504 A1
反应条件
1.1: acetic acid / dichloromethane / 0.25 h / 0 °C 1.2: 16 h / 0 - 20 °C 2.1: dichloromethane / 0.5 h / 0 - 20 °C 3.1: trifluoroacetic acid / dichloromethane / 1 h / 0 °C View Scheme
参考文献
Synthetic Communications, , vol. 43, # 13 p. 1796 - 1801
反应条件
in 1,4-dioxane 20 h; Reflux;
参考文献
US2013/237538 A1, ;
Paragraph 0252 ;
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 17, # 18 p. 5019 - 5024
反应条件
1: Mg / tetrahydrofuran 2: 50percent aq. HCl / Heating View Scheme
参考文献
Bottcher; Barnickel; Hausberg; Haase; Seyfried; Eiermann
Journal of Medicinal Chemistry, 1992 , vol. 35, # 22 p. 4020 - 4026
