N-叔丁氧羰基-4-哌啶酮合成路线 （共 500 条）
反应条件
boron trifluoride diethyl etherate in diethyl ether; dichloromethane
参考文献
PFIZER PRODUCTS INC.
Patent: WO2008/65500 A2, 2008 ;
Location in patent: Page/Page column 51; 52 ;
WO 2008/065500 A2
反应条件
1: boron trifluoride diethyl etherate / diethyl ether / 1 h / -20 °C 2: lithium hydroxide hydrate / tetrahydrofuran; water / 18 h / 20 - 80 °C View Scheme
参考文献
3-V BIOSCIENCES, INC.; OSLOB, Johan D.; MCDOWELL, Robert S.; JOHNSON, Russell; YANG, Hanbiao; EVANCHIK, Marc; ZAHARIA, Cristiana A.; CAI, Haiying; HU, Lily W.
Patent: WO2014/8197 A1, 2014 ;
反应条件
sulfur; L-proline in N,N-dimethyl-formamide T=60°C; Gewald reaction; 20 h;
参考文献
Wang, Tao; Huang, Xian-Gui; Liu, Jia; Li, Bo; Wu, Jin-Jin; Chen, Kai-Xian; Zhu, Wei-Liang; Xu, Xiao-Yong; Zeng, Bu-Bing
Synlett, 2010 , # 9 p. 1351 - 1354
反应条件
hydroxylamine hydrochloride; sodium acetate in ethanol; water
参考文献
Mullen, Philip; Miel, Hugues; Anthony McKervey
Tetrahedron Letters, 2010 , vol. 51, # 24 p. 3216 - 3217
反应条件
hydroxylamine hydrochloride in methanol
参考文献
SmithKline Beecham Corporation
Patent: US6077857 A1, 2000 ;
反应条件
triethylamine in methanol; chloroform; hydroxylamine hydrochloride
参考文献
Kaken Pharmaceutical Co., Ltd.
Patent: US5276041 A1, 1994 ;
反应条件
1.1: n-butyllithium / tetrahydrofuran / 2.5 h / -78 °C / |Inert atmosphere 1.2: 0.5 h / -78 °C / |Inert atmosphere 2.1: tetrakis(triphenylphosphine) palladium(0) / N,N-dimethyl-formamide / 80 °C / |Inert atmosphere 3.1: trichlorophosphate / pyridine / 20 °C / |Inert atmosphere 4.1: palladium 10 on activated carbon; hydrogen / ethyl acetate / 20 °C 5.1: hydrogenchloride / ethyl acetate / 1 h / 20 °C View Scheme
参考文献
Oslob, Johan D.; Johnson, Russell J.; Cai, Haiying; Feng, Shirley Q.; Hu, Lily; Kosaka, Yuko; Lai, Julie; Sivaraja, Mohanram; Tep, Samnang; Yang, Hanbiao; Zaharia, Cristiana A.; Evanchik, Marc J.; McDowell, Robert S.
ACS Medicinal Chemistry Letters, 2013 , vol. 4, # 1 p. 113 - 117
反应条件
1: in dichloromethane T=20°C; 1 h; 2: With sodium tris(acetoxy)borohydride in dichloromethane T=20°C; 24 h;
参考文献
Yang, Shyh-Ming; Tang, Yuting; Zhang, Rui; Lu, Huajun; Kuo, Gee-Hong; Gaul, Michael D.; Li, Yaxin; Ho, George; Conway, James G.; Liang, Yin; Lenhard, James M.; Demarest, Keith T.; Murray, William V.
Bioorganic and Medicinal Chemistry Letters, 2013 , vol. 23, # 24 p. 6773 - 6776
反应条件
1: KOH / methanol / 60 °C 2: H2 / Pd/C / ethanol View Scheme
参考文献
Cole, Derek C.; Ellingboe, John W.; Lennox, William J.; Mazandarani, Hossein; Smith, Deborah L.; Stock, Joseph R.; Zhang, Guoming; Zhou, Ping; Schechter, Lee E.
Bioorganic and Medicinal Chemistry Letters, 2005 , vol. 15, # 2 p. 379 - 383
反应条件
1: hydroxylamine hydrochloride; sodium acetate / methanol; water / Reflux 2: 1-propanephosphonic acid cyclic anhydride / tetrahydrofuran; ethyl acetate / 70 °C / Inert atmosphere View Scheme
参考文献
Augustine, John Kallikat; Kumar, Rajesha; Bombrun, Agnes; Mandal, Ashis Baran
Tetrahedron Letters, 2011 , vol. 52, # 10 p. 1074 - 1077
