反应条件
1: toluene / 24 h / Reflux
2: hydroquinone / toluene / 24 h / Reflux
3: lithium hexamethyldisilazane / tetrahydrofuran / -63 - -60 °C
4: chloro-trimethyl-silane / tetrahydrofuran / 2 h / -70 °C
5: palladium diacetate / acetonitrile / 35 °C
6: tetrabutyl ammonium fluoride / ethyl acetate / 0.5 h
7: pyridine / dichloromethane / -30 - 20 °C / Inert atmosphere
8: tetrakis(triphenylphosphine) palladium(0) / N,N-dimethyl-formamide / 6 h / 100 °C / Inert atmosphere
View Scheme
参考文献
Demont, Emmanuel H.; Andrews, Benjamin I.; Bit, Rino A.; Campbell, Colin A.; Cooke, Jason W. B.; Deeks, Nigel; Desai, Sapna; Dowell, Simon J.; Gaskin, Pam; Gray, James R. J.; Haynes, Andrea; Holmes, Duncan S.; Kumar, Umesh; Morse, Mary A.; Osborne, Greg J.; Panchal, Terry; Patel, Bela; Perboni, Alcide; Taylor, Simon; Watson, Robert; Witherington, Jason; Willis, Robert
ACS Medicinal Chemistry Letters, 2011 , vol. 2, # 6 p. 444 - 449