N-叔丁氧羰基-4-哌啶酮合成路线 （共 500 条）
反应条件
sodium tris(acetoxy)borohydride; acetic acid in 1,2-dichloro-ethane
T=25°C;
参考文献
Bourdonnec, Bertrand Le; Leister, Lara K.; Ajello, Christopher A.; Cassel, Joel A.; Seida, Pamela R.; O'Hare, Heather; Gu, Minghua; Chu, Guo-Hua; Tuthill, Paul A.; DeHaven, Robert N.; Dolle, Roland E.
Bioorganic and Medicinal Chemistry Letters, 2008 , vol. 18, # 1 p. 336 - 343
反应条件
sodium ethanolate in ethanol
T=20°C;
参考文献
3M INNOVATIVE PROPERTIES COMPANY
Patent: WO2006/28545 A2, 2006 ;
Location in patent: Page/Page column 91 ;
反应条件
titanium tetrachloride; zinc in tetrahydrofuran
T=20°C; McMurray condensation; 2 h; Heating / reflux;
参考文献
Carson, John R.; Dax, Scott L.; DeCorte, Bart; Liu, Li; McDonnell, Mark; McNally, James J.
Patent: US2006/135522 A1, 2006 ;
Location in patent: Page/Page column 20 ;
US 20060135522 A1
反应条件
1: 1.) t-bytyllithium, 2.) t-butoxide / 1.) pentane, THF, a) -70 deg, 0.5 h, b) -20 deg, 2.5 h, 2.) THF, a) from -70 deg to RT, 4 h, b) RT, 16 h
2: 1.) NaH / 1.) DMF, 20 deg, 0.5 h, 2.) DMF, 20 deg, 1 h
3: 78 percent / trifluoroacetic acid / CH2Cl2 / 2 h / Ambient temperature
View Scheme
参考文献
Clark; Caroon; Kluge; Repke; Roszkowski; Strosberg; Baker; Bitter; Okada
Journal of Medicinal Chemistry, 1983 , vol. 26, # 5 p. 657 - 661
反应条件
iodine; potassium hydroxide
T=0 - 20°C; 2.5 h;
参考文献
Surmont, Riccardo; Verniest, Guido; De Weweire, Arvid; Thuring, Jan Willem; Macdonald, Gregor; Deroose, Frederik; De Kimpe, Norbert
Synlett, 2009 , # 12 p. 1933 - 1936
反应条件
sodium iodide in methanol
T=30°C; Electrochemical reaction;
参考文献
Elinson, Michail N.; Dorofeev, Alexander S.; Feducovich, Sergey K.; Nasybullin, Ruslan F.; Litvin, Evgeny F.; Kopyshev, Mikhail V.; Nikishin, Gennady I.
Tetrahedron, 2006 , vol. 62, # 34 p. 8021 - 8028
反应条件
1: sodium tris(acetoxy)borohydride / dichloromethane / 24 h / 20 °C
2: trifluoroacetic acid / dichloromethane / 3 h / 20 °C
View Scheme
参考文献
Yang, Shyh-Ming; Tang, Yuting; Rano, Thomas; Lu, Huajun; Kuo, Gee-Hong; Gaul, Michael D.; Li, Yaxin; Ho, George; Lang, Wensheng; Conway, James G.; Liang, Yin; Lenhard, James M.; Demarest, Keith T.; Murray, William V.
Bioorganic and Medicinal Chemistry Letters, 2014 , vol. 24, # 5 p. 1437 - 1441
反应条件
1.1: BuLi / tetrahydrofuran; hexane / 0.5 h / -78 °C
1.2: 61 percent / tetrahydrofuran; hexane / -78 - 20 °C
2.1: 83 percent / trifluoroacetic acid / CH2Cl2 / 0.5 h
View Scheme
参考文献
Kamei, Katsuhide; Maeda, Noriko; Katsuragi-Ogino, Ryoko; Koyama, Makoto; Nakajima, Mika; Tatsuoka, Toshio; Ohno, Tomochika; Inoue, Teruyoshi
Bioorganic and Medicinal Chemistry Letters, 2005 , vol. 15, # 12 p. 2990 - 2993
反应条件
10 palladium on activated carbon; hydrogen in methanol
T=20°C; P=760.051 Torr; 18 h;
参考文献
Yokoyama, Kazuhiro; Ishikawa, Noriko; Igarashi, Susumu; Kawano, Noriyuki; Masuda, Naoyuki; Hamaguchi, Wataru; Yamasaki, Shingo; Koganemaru, Yohei; Hattori, Kazuyuki; Miyazaki, Takahiro; Ogino, Shin-ichi; Matsumoto, Yuzo; Takeuchi, Makoto; Ohta, Mitsuaki
Bioorganic and Medicinal Chemistry, 2009 , vol. 17, # 1 p. 64 - 73
反应条件
1.1: acetic acid / dichloromethane / 3 h / 20 °C
1.2: 18 h / 20 °C
2.1: [bis(2-methoxyethyl)amino]-sulfur trifluoride / 2.5 h / -78 - 20 °C
3.1: hydrogenchloride / 1,4-dioxane / 18 h / 20 °C
View Scheme
参考文献
GLAXOSMITHKLINE LLC; BROOKS, Carl, A.; CHEUNG, Mui; EIDAM, Hilary, S.; FOX, Ryan, M.; HILFIKER, Mark, A.; MANAS, Eric, S.; YE, Guosen
Patent: WO2011/119701 A1, 2011 ;
WO 2011/119701 A1
