N-叔丁氧羰基-4-哌啶酮合成路线 （共 500 条）
反应条件
10 palladium on activated carbon; hydrogen in methanol
T=20°C; P=760.051 Torr; 48 h;
参考文献
Yokoyama, Kazuhiro; Ishikawa, Noriko; Igarashi, Susumu; Kawano, Noriyuki; Masuda, Naoyuki; Hamaguchi, Wataru; Yamasaki, Shingo; Koganemaru, Yohei; Hattori, Kazuyuki; Miyazaki, Takahiro; Ogino, Shin-ichi; Matsumoto, Yuzo; Takeuchi, Makoto; Ohta, Mitsuaki
Bioorganic and Medicinal Chemistry, 2009 , vol. 17, # 1 p. 64 - 73
参考文献
Chen, Jian Jeffrey; Dewdney, Nolan; Lin, Xiaohong; Martin, Robert L.; Walker, Keith A. M.; Huang, Jane; Chu, Frances; Eugui, Elsie; Mirkovich, Anna; Kim, Yong; Sarma, Keshab; Arzeno, Humberto; Van Wart, Harold E.
Bioorganic and Medicinal Chemistry Letters, 2003 , vol. 13, # 22 p. 3951 - 3954
反应条件
1: 1-bromo-3-chlorobenzene With magnesium; iodine in tetrahydrofuran
T=0 - 20°C; Inert atmosphere;
2: tert-butyl 4-oxo-piperidine-1-carboxylate in tetrahydrofuran
T=20°C; Inert atmosphere;
3: With water; ammonium chloride in tetrahydrofuran
Saturated solution;
参考文献
Gruenenthal GmbH
Patent: US2009/264400 A1, 2009 ;
Location in patent: Page/Page column 97 ;
US 20090264400 A1
反应条件
1: in tetrahydrofuran
T=0 - 20°C; Inert atmosphere;
2: With ammonium chloride
参考文献
Almirall, S.A.; Vidal Juan, Bernat; Fernandez Collado, Juan Carlos; Erra Sola, Montserrat; Aguilar Izquierdo, Nuria; Mir Cepeda, Marta; Carranco Moruno, Inés
Patent: EP2489663 A1, 2012 ;
Location in patent: Paragraph 0102; 0103; 0104 ;
EP 2489663 A1
反应条件
1: m-ClC6H4Hal With magnesium in tetrahydrofuran
2: tert-butyl 4-oxo-piperidine-1-carboxylate in tetrahydrofuran
参考文献
Kumagai, Toshihito; Okubo, Taketoshi; Kataoka-Okubo, Hiromi; Chaki, Shigeyuki; Okuyama, Shigeru; Nakazato, Atsuro
Bioorganic and Medicinal Chemistry, 2001 , vol. 9, # 5 p. 1357 - 1363
反应条件
1: 2-nitrobenzylamine hydrochloride With triethylamine in 1,2-dichloro-ethane
T=20°C; 0.0833333 h;
2: tert-butyl 4-oxo-piperidine-1-carboxylate With sodium tris(acetoxy)borohydride; acetic acid in 1,2-dichloro-ethane
T=20°C; 1 h;
3: With water; sodium carbonate in 1,2-dichloro-ethane
参考文献
NEUROGEN CORPORATION
Patent: WO2008/70014 A2, 2008 ;
Location in patent: Page/Page column 58 ;
WO 2008/070014 A2
反应条件
1.1: acetic acid / dichloromethane / 0.25 h / 0 °C
1.2: 16 h / 0 - 20 °C
2.1: dichloromethane / 0.5 h / 0 - 20 °C
View Scheme
参考文献
Rasheed, Mohammed Abdul; Shaik, Nagul Meera; Nirogi, Ramakrishna
Synthetic Communications, 2013 , vol. 43, # 13 p. 1796 - 1801
反应条件
1: lithium hexamethyldisilazane / tetrahydrofuran / 19 h / -78 - 20 °C / |Inert atmosphere
2: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium carbonate / water; 1,4-dioxane / 16 h / 80 - 90 °C / |Inert atmosphere
View Scheme
参考文献
AFRAXIS, INC.; CAMPBELL, David; DURÓN, Sergio, G.
Patent: WO2013/43232 A2, 2013 ;
WO 2013/043232 A2
反应条件
1.1: diisopropylamine; n-butyllithium / tetrahydrofuran / 2 h / -78 °C
1.2: 5 h / -78 - -70 °C
2.1: tetrakis(triphenylphosphine) palladium(0) / dimethyl sulfoxide / 2 h / 100 °C
View Scheme
参考文献
SYNGENTA PARTICIPATIONS AG; LAMBERTH, Clemens; SULZER-MOSSE, Sarah; CEDERBAUM, Fredrik; UMARYE, Jayant; SONAWANE, Ravindra
Patent: WO2013/127808 A1, 2013 ;
反应条件
1: sulfur; triethylamine / 16 h / 20 °C
2: N,N-dimethyl-formamide / 16 h / 100 °C
View Scheme
参考文献
Hamed, Mostafa M.; Abou El Ella, Dalal A.; Keeton, Adam B.; Piazza, Gary A.; Engel, Matthias; Hartmann, Rolf W.; Abadi, Ashraf H.
MedChemComm, 2013 , vol. 4, # 8 p. 1202 - 1207
