N-叔丁氧羰基-4-哌啶酮合成路线 （共 500 条）
反应条件
1: S8; morpholine / ethanol / 1 h / 70 °C
2: pyridine / CH2Cl2 / 2 h / 20 °C
3: TFA / CH2Cl2 / 2 h / 20 °C
4: MnO2 / toluene / 0.08 h / 120 °C / microwave irradiation
View Scheme
参考文献
Romagnoli, Romeo; Baraldi, Pier Giovanni; Moorman, Allan R.; Iaconinoto, Maria Antonietta; Carrion, Maria Dora; Cara, Carlota Lopez; Tabrizi, Mojgan Aghazadeh; Preti, Delia; Fruttarolo, Francesca; Baker, Stephen P.; Varani, Katia; Borea, Pier Andrea
Bioorganic and Medicinal Chemistry Letters, 2006 , vol. 16, # 21 p. 5530 - 5533
反应条件
1: S8; morpholine / ethanol / 1 h / 70 °C
2: pyridine / CH2Cl2 / 2 h / 20 °C
3: TFA / CH2Cl2 / 2 h / 20 °C
4: MnO2 / toluene / 0.08 h / 120 °C / microwave irradiation
View Scheme
参考文献
Romagnoli, Romeo; Baraldi, Pier Giovanni; Moorman, Allan R.; Iaconinoto, Maria Antonietta; Carrion, Maria Dora; Cara, Carlota Lopez; Tabrizi, Mojgan Aghazadeh; Preti, Delia; Fruttarolo, Francesca; Baker, Stephen P.; Varani, Katia; Borea, Pier Andrea
Bioorganic and Medicinal Chemistry Letters, 2006 , vol. 16, # 21 p. 5530 - 5533
反应条件
1: S8; morpholine / ethanol / 1 h / 70 °C
2: pyridine / CH2Cl2 / 2 h / 20 °C
3: TFA / CH2Cl2 / 2 h / 20 °C
4: MnO2 / toluene / 0.08 h / 120 °C / microwave irradiation
View Scheme
参考文献
Romagnoli, Romeo; Baraldi, Pier Giovanni; Moorman, Allan R.; Iaconinoto, Maria Antonietta; Carrion, Maria Dora; Cara, Carlota Lopez; Tabrizi, Mojgan Aghazadeh; Preti, Delia; Fruttarolo, Francesca; Baker, Stephen P.; Varani, Katia; Borea, Pier Andrea
Bioorganic and Medicinal Chemistry Letters, 2006 , vol. 16, # 21 p. 5530 - 5533
反应条件
1: S8; morpholine / ethanol / 1 h / 70 °C
2: pyridine / CH2Cl2 / 2 h / 20 °C
3: TFA / CH2Cl2 / 2 h / 20 °C
4: MnO2 / toluene / 0.08 h / 120 °C / microwave irradiation
View Scheme
参考文献
Romagnoli, Romeo; Baraldi, Pier Giovanni; Moorman, Allan R.; Iaconinoto, Maria Antonietta; Carrion, Maria Dora; Cara, Carlota Lopez; Tabrizi, Mojgan Aghazadeh; Preti, Delia; Fruttarolo, Francesca; Baker, Stephen P.; Varani, Katia; Borea, Pier Andrea
Bioorganic and Medicinal Chemistry Letters, 2006 , vol. 16, # 21 p. 5530 - 5533
反应条件
1: S8; morpholine / ethanol / 1 h / 70 °C
2: pyridine / CH2Cl2 / 2 h / 20 °C
3: TFA / CH2Cl2 / 2 h / 20 °C
4: MnO2 / toluene / 0.08 h / 120 °C / microwave irradiation
View Scheme
参考文献
Romagnoli, Romeo; Baraldi, Pier Giovanni; Moorman, Allan R.; Iaconinoto, Maria Antonietta; Carrion, Maria Dora; Cara, Carlota Lopez; Tabrizi, Mojgan Aghazadeh; Preti, Delia; Fruttarolo, Francesca; Baker, Stephen P.; Varani, Katia; Borea, Pier Andrea
Bioorganic and Medicinal Chemistry Letters, 2006 , vol. 16, # 21 p. 5530 - 5533
反应条件
1: S8; morpholine / ethanol / 1 h / 70 °C
2: pyridine / CH2Cl2 / 2 h / 20 °C
3: TFA / CH2Cl2 / 2 h / 20 °C
4: MnO2 / toluene / 0.08 h / 120 °C / microwave irradiation
View Scheme
参考文献
Romagnoli, Romeo; Baraldi, Pier Giovanni; Moorman, Allan R.; Iaconinoto, Maria Antonietta; Carrion, Maria Dora; Cara, Carlota Lopez; Tabrizi, Mojgan Aghazadeh; Preti, Delia; Fruttarolo, Francesca; Baker, Stephen P.; Varani, Katia; Borea, Pier Andrea
Bioorganic and Medicinal Chemistry Letters, 2006 , vol. 16, # 21 p. 5530 - 5533
反应条件
1: S8; morpholine / ethanol / 1 h / 70 °C
2: pyridine / CH2Cl2 / 2 h / 20 °C
3: TFA / CH2Cl2 / 2 h / 20 °C
4: MnO2 / toluene / 0.08 h / 120 °C / microwave irradiation
View Scheme
参考文献
Romagnoli, Romeo; Baraldi, Pier Giovanni; Moorman, Allan R.; Iaconinoto, Maria Antonietta; Carrion, Maria Dora; Cara, Carlota Lopez; Tabrizi, Mojgan Aghazadeh; Preti, Delia; Fruttarolo, Francesca; Baker, Stephen P.; Varani, Katia; Borea, Pier Andrea
Bioorganic and Medicinal Chemistry Letters, 2006 , vol. 16, # 21 p. 5530 - 5533
反应条件
1: S8; morpholine / ethanol / 1 h / 70 °C
2: pyridine / CH2Cl2 / 2 h / 20 °C
3: TFA / CH2Cl2 / 2 h / 20 °C
4: MnO2 / toluene / 0.08 h / 120 °C / microwave irradiation
View Scheme
参考文献
Romagnoli, Romeo; Baraldi, Pier Giovanni; Moorman, Allan R.; Iaconinoto, Maria Antonietta; Carrion, Maria Dora; Cara, Carlota Lopez; Tabrizi, Mojgan Aghazadeh; Preti, Delia; Fruttarolo, Francesca; Baker, Stephen P.; Varani, Katia; Borea, Pier Andrea
Bioorganic and Medicinal Chemistry Letters, 2006 , vol. 16, # 21 p. 5530 - 5533
反应条件
1: S8; morpholine / ethanol / 1 h / 70 °C
2: pyridine / CH2Cl2 / 2 h / 20 °C
3: TFA / CH2Cl2 / 2 h / 20 °C
4: MnO2 / toluene / 0.08 h / 120 °C / microwave irradiation
View Scheme
参考文献
Romagnoli, Romeo; Baraldi, Pier Giovanni; Moorman, Allan R.; Iaconinoto, Maria Antonietta; Carrion, Maria Dora; Cara, Carlota Lopez; Tabrizi, Mojgan Aghazadeh; Preti, Delia; Fruttarolo, Francesca; Baker, Stephen P.; Varani, Katia; Borea, Pier Andrea
Bioorganic and Medicinal Chemistry Letters, 2006 , vol. 16, # 21 p. 5530 - 5533
反应条件
1: With pyrrolidine in methanol
T=80°C; 16 h;
2: With hydrogenchloride in 1,4-dioxane; dichloromethane
T=20°C; 16 h;
参考文献
UNIVERSITY HEALTH NETWORK; PAULS, Heinz W.; LAUFER, Radoslaw; LIU, Yong; LI, Sze-Wan; FORREST, Bryan T.; LANG, Yunhui; PATEL, Narendra Kumar B.; EDWARDS, Louise G.; NG, Grace; SAMPSON, Peter Brent; FEHER, Miklos; AWREY, Donald E.
Patent: WO2013/53051 A1, 2013 ;
Location in patent: Page/Page column 93 ;
