N-叔丁氧羰基-4-哌啶酮合成路线 （共 500 条）
反应条件
ammonium acetate; acetic acid; benzene
参考文献
Chauder, Brian A.; Boros, Eric E.; Du, Kien S.; Kazmierski, Wieslaw M.; Koble, Cecilia S.; Thompson, James B.; Tabet, Elie A.
Synthetic Communications, 2006 , vol. 36, # 3 p. 279 - 284
反应条件
1: bromo[(3,4-dichlorophenyl)methyl]triphenylphosphorane With n-butyllithium in tetrahydrofuran; pentane T=0 - 20°C; 2.25 h; 2: tert-butyl 4-oxo-piperidine-1-carboxylate in tetrahydrofuran; pentane Wittig Reaction;
参考文献
Gong, Leyi; Wilhelm, Robert Stephen
Patent: US2005/90504 A1, 2005 ;
Location in patent: Page/Page column 13 ;
US 20050090504 A1
反应条件
triphenylphosphine in tetrahydrofuran; methanol; hexane; dichloromethane; pentane
参考文献
Syntex (U.S.A.) LLC
Patent: US6323223 B1, 2001 ;
反应条件
triphenylphosphine in tetrahydrofuran; methanol; hexane; dichloromethane; pentane
参考文献
Syntex (U.S.A.) Inc.
Patent: US6140344 A1, 2000 ;
US 6140344 A
反应条件
1.1: ethanol; sodium tetrahydroborate / 0.5 h / 0 - 23 °C 2.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0 °C 2.2: 2 h / 0 - 23 °C View Scheme
参考文献
HETERO RESEARCH FOUNDATION; PANDURANGA ADULLA, Reddy; PARTHASARADHI REDDY, Bandi; MANOHAR SHARMA, Vedula; RATHNAKAR REDDY, Kura; PREM KUMAR, Mamnoor; BHASKAR REDDY, Kasireddy; NARSINGAM, Mogili; VENKATI, Mukkera; VL SUBRAHMANYAM, Lanka; MALLIKARJUN REDDY, Ravi
Patent: WO2013/160810 A2, 2013 ;
反应条件
1: 2-methoxybromobenzene With n-butyllithium in tetrahydrofuran; hexane T=-78°C; 0.833333 h; Argon gasification; 2: tert-butyl 4-oxo-piperidine-1-carboxylate in tetrahydrofuran; hexane 4.16667 h;
参考文献
Meiji Seika Kaisha, Ltd.
Patent: US6355642 B1, 2002 ;
Location in patent: Page column 19 ;
反应条件
in tetrahydrofuran T=0°C; Grignard Reaction; 2 h;
参考文献
Choi, Yeon Jae; Seo, Jae Hong; Shin, Kye Jung
Bioorganic and Medicinal Chemistry Letters, 2014 , vol. 24, # 3 p. 880 - 883
反应条件
1.1: Mg / tetrahydrofuran 1.2: 77 percent / 1 h / 0 °C 2.1: 92 percent / TFA / CH2Cl2 / 12 h / 20 °C 3.1: 88 percent / H2 / Pd/C / methanol / 12 h / 20 °C View Scheme
参考文献
Annoura, Hirokazu; Nakanishi, Kyoko; Uesugi, Mayumi; Miyajima, Atsuko Fukunaga Atsuko; Tamura-Horikawa, Yoshiko; Tamura, Shigeki
Bioorganic and Medicinal Chemistry Letters, 1999 , vol. 9, # 20 p. 2999 - 3002
反应条件
triethylamine in N,N-dimethyl-formamide T=80°C; 16 h;
参考文献
ARRAY BIOPHARMA INC.
Patent: WO2008/124323 A1, 2008 ;
Location in patent: Page/Page column 39-40 ;
WO 2008/124323 A1
反应条件
chloro-trimethyl-silane; triethylamine in DMF (N,N-dimethyl-formamide) T=80°C;
参考文献
ASTRAZENECA AB
Patent: WO2004/5295 A1, 2004 ;
Location in patent: Page 61-62 ;
