sodium tetrahydroborate in methanol 5 h; Ambient temperature;

1: 1) TEA; 2) NaBH4 / 1) room temp., 1 h; 2) room temp. 2h 2: 46.4 percent / hydrogen / 10percent Pd-C / H2O / Ambient temperature 3: 54.5 percent / TEA / acetonitrile / 4 h / Ambient temperature 4: 83.1 percent / hydrogen, 1 N aq.HCl / 10percent Pd-C / methanol / 5 h / 40 °C 5: 48 percent / TEA / methanol / Ambient temperature 6: 56.6 percent / NaBH4 / methanol / 5 h / Ambient temperature View Scheme

1: 83.1 percent / hydrogen, 1 N aq.HCl / 10percent Pd-C / methanol / 5 h / 40 °C 2: 48 percent / TEA / methanol / Ambient temperature 3: 56.6 percent / NaBH4 / methanol / 5 h / Ambient temperature View Scheme

1: 54.5 percent / TEA / acetonitrile / 4 h / Ambient temperature 2: 83.1 percent / hydrogen, 1 N aq.HCl / 10percent Pd-C / methanol / 5 h / 40 °C 3: 48 percent / TEA / methanol / Ambient temperature 4: 56.6 percent / NaBH4 / methanol / 5 h / Ambient temperature View Scheme

1: 46.4 percent / hydrogen / 10percent Pd-C / H2O / Ambient temperature 2: 54.5 percent / TEA / acetonitrile / 4 h / Ambient temperature 3: 83.1 percent / hydrogen, 1 N aq.HCl / 10percent Pd-C / methanol / 5 h / 40 °C 4: 48 percent / TEA / methanol / Ambient temperature 5: 56.6 percent / NaBH4 / methanol / 5 h / Ambient temperature View Scheme

1: 1) TEA; 2) NaBH4 / 1) room temp., 1 h; 2) room temp. 2h 2: 46.4 percent / hydrogen / 10percent Pd-C / H2O / Ambient temperature 3: 54.5 percent / TEA / acetonitrile / 4 h / Ambient temperature 4: 83.1 percent / hydrogen, 1 N aq.HCl / 10percent Pd-C / methanol / 5 h / 40 °C 5: 48 percent / TEA / methanol / Ambient temperature 6: 56.6 percent / NaBH4 / methanol / 5 h / Ambient temperature View Scheme

1: 48 percent / TEA / methanol / Ambient temperature 2: 56.6 percent / NaBH4 / methanol / 5 h / Ambient temperature View Scheme

1: 48 percent / TEA / methanol / Ambient temperature 2: 56.6 percent / NaBH4 / methanol / 5 h / Ambient temperature View Scheme