4-氯-5,7-二氟喹唑啉合成路线 （共 2 条）
反应条件
N-ethyl-N,N-diisopropylamine; trichlorophosphate in acetonitrile
T=0 - 80°C; 4.75 h; Heating / reflux;
参考文献
ASTRAZENECA AB; ASTRAZENECA UK LIMITED
Patent: WO2006/64217 A2, 2006 ;
Location in patent: Page/Page column 54-55 ;
WO 2006/064217 A2
反应条件
1: 3 h / 44 °C / Large scale reaction
2: sodium tert-pentoxide / 1-methyl-pyrrolidin-2-one / 5 h / 55 °C / Large scale reaction
View Scheme
参考文献
Raw, Steven A.; Taylor, Brian A.; Tomasi, Simone
Organic Process Research and Development, 2011 , vol. 15, # 3 p. 688 - 692
