反应条件
1.1: 80 percent / CuI; trans-cyclohexane-1,3-diamine; K2CO3 / dioxane / 125 °C
2.1: lithium hexamethyldisilazide / tetrahydrofuran / 0.5 h / -78 °C
2.2: tetrahydrofuran / -78 - 20 °C
3.1: ethanol; H2O / 3 h / 100 °C
View Scheme
参考文献
Beadle, Christopher D.; Boot, John; Camp, Nicholas P.; Dezutter, Nancy; Findlay, Jeremy; Hayhurst, Lorna; Masters, John J.; Penariol, Roberta; Walter, Magnus W.
Bioorganic and Medicinal Chemistry Letters, 2005 , vol. 15, # 20 p. 4432 - 4437
