1: 96 percent / sodium hydride / dimethylformamide / 16 h / 20 °C 2: 60 percent / H2SO4 / acetic acid / 1.5 h / 0 °C 3: 98.9 percent / HCl / CH2Cl2 / 48 h / 20 °C 4: 1.) AgSO3CF3, Me2NCONMe2; 2.) NaOMe / 1.) CH2Cl2, 20 deg C, 16 h; 2.) MeOH, 20 deg C, 16 h View Scheme

1: 96 percent / sodium hydride / dimethylformamide / 16 h / 20 °C 2: 60 percent / H2SO4 / acetic acid / 1.5 h / 0 °C View Scheme