lithium diisopropyl amide in tetrahydrofuran 1. -78 deg C, 2.5 h; 2. H2O, room temperature, 3 h;

1: 74.5 percent / KOH / 0.5 h / 10 °C 2: 78 percent / lithium diisopropylamide / tetrahydrofuran / 1. -78 deg C, 2.5 h; 2. H2O, room temperature, 3 h View Scheme

1: LDA 2: 15 h / Ambient temperature; pH = 3, acid hydrolysis View Scheme