2-(1H-吡咯-1-基)噻吩-3-羧酸合成路线 （共 5 条）
反应条件
sodium hydroxide; water in methanol
3 h; Heating;
参考文献
Rault, Sylvain; Lancelot, Jean-Charles; Prunier, Herve; Robba, Max; Renard, Pierre; Delagrange, Philippe; Pfeiffer, Bruno; Caignard, Daniel-Henri; Guardiola-Lemaitre, Beatrice; Hamon, Michel
Journal of Medicinal Chemistry, 1996 , vol. 39, # 10 p. 2068 - 2080
反应条件
1: AcOH / 2 h / Heating
2: NaOH, H2O / methanol / 3 h / Heating
View Scheme
参考文献
Rault, Sylvain; Lancelot, Jean-Charles; Prunier, Herve; Robba, Max; Renard, Pierre; Delagrange, Philippe; Pfeiffer, Bruno; Caignard, Daniel-Henri; Guardiola-Lemaitre, Beatrice; Hamon, Michel
Journal of Medicinal Chemistry, 1996 , vol. 39, # 10 p. 2068 - 2080
反应条件
sodium hydroxide; water in methanol
4 h; Reflux;
参考文献
Lemaitre, Stephane; Lepailleur, Alban; Bureau, Ronan; Butt-Gueulle, Sabrina; Lelong-Boulouard, Veronique; Duchatelle, Pascal; Boulouard, Michel; Dumuis, Aline; Daveu, Cyril; Lezoualc'h, Frank; Pfeiffer, Bruno; Dauphin, Francois; Rault, Sylvain
Bioorganic and Medicinal Chemistry, 2009 , vol. 17, # 6 p. 2607 - 2622
反应条件
4-chloro pyridine hydrochloride in 1,4-dioxane
Reflux;
参考文献
Grande, Fedora; Brizzi, Antonella; Garofalo, Antonio; Aiello, Francesca
Tetrahedron, 2013 , vol. 69, # 47 p. 9951 - 9956
反应条件
1: TEA, ClCO2Et, NaN3 / acetone; acetonitrile / 0 °C
2: 2 h / Heating
3: NaOH / H2O / 5 h / Heating
View Scheme
参考文献
Rault, Sylvain; Lancelot, Jean-Charles; Prunier, Herve; Robba, Max; Renard, Pierre; Delagrange, Philippe; Pfeiffer, Bruno; Caignard, Daniel-Henri; Guardiola-Lemaitre, Beatrice; Hamon, Michel
Journal of Medicinal Chemistry, 1996 , vol. 39, # 10 p. 2068 - 2080
