2,5-二溴-4-甲基噻唑合成路线 （共 5 条）
反应条件
sulfuric acid; copper(II) sulfate; sodium bromide; sodium nitrite in water 1.) 3 deg C, 30 min, 2.) 20 deg C, 30 min;
参考文献
Kaye, Perry T.; Meakins, G. Denis; Willbe, Charles; Williams, Peter R.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1981 , p. 2335 - 2339
反应条件
hydrogen bromide; sodium nitrite anschliessendes Erwaermen mit Brom;
参考文献
Yakugaku Zasshi, , vol. 67, p. 193
Chem.Abstr., , p. 9036
反应条件
1: 2,5-dibromo-4-methylthiazole With n-butyllithium in hexane
T=-70°C; 1 h;
2: carbon dioxide in hexane
参考文献
Boehringer Ingelheim (Canada) Ltd.
Patent: US2003/236251 A1, 2003 ;
Location in patent: Page 28 ;
反应条件
n-butyllithium
1.) hexane, -60 deg C, 1 h, 2.) ether, 3.) ether, 5 min; Yield given. Multistep reaction;
参考文献
Kaye, Perry T.; Meakins, G. Denis; Willbe, Charles; Williams, Peter R.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1981 , p. 2335 - 2339
反应条件
n-butyllithium; sulfuric acid
1.) hexane, -60 deg C, 1 h, 2.) ether, 3.) 20 deg C, 10 d; Yield given. Multistep reaction;
参考文献
Kaye, Perry T.; Meakins, G. Denis; Willbe, Charles; Williams, Peter R.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1981 , p. 2335 - 2339
