反应条件
1: 27 percent / 1 h / 230 °C
2: SOCl2, DMF / 3 h
3: 0.5 h
4: 1.) O3, 2.) (CH3)2S / 1.) MeOH, -70 deg C, 15 min, 2.) MeOH, RT, overnight
5: 85percent H3PO4 / 100 °C
View Scheme
参考文献
Eissenstat, Michael A.; Bell, Malcolm R.; D'Ambra, Thomas E.; Alexander, E. John; Daum, Sol J.; et al.
Journal of Medicinal Chemistry, 1995 , vol. 38, # 16 p. 3094 - 3105
