3,4-二氢一异喹啉-2,3-二甲酸-2-苄酯合成路线 （共 11 条）
反应条件
sodium hydrogencarbonate in water T=20°C; 1.5 h;
参考文献
Tarver Jr.; Pfizenmayer; Joullie
Journal of Organic Chemistry, 2001 , vol. 66, # 23 p. 7575 - 7587
反应条件
sodium hydroxide in N,N-dimethyl-formamide T=0 - 20°C; 27 h;
参考文献
Salvadori, Severe; Balboni, Gianfranco; Guerrini, Remo; Tomatis, Roberto; Bianchi, Clementina; Bryant, Sharon D.; Cooper, Peter S.; Lazarus, Lawrence H.
Journal of Medicinal Chemistry, 1997 , vol. 40, # 19 p. 3100 - 3108
反应条件
1: (3S)-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid hydrochloride With sodium hydrogencarbonate in 1,4-dioxane; water T=0°C; Schotten-Baumann reaction; 2: benzyl chloroformate in 1,4-dioxane; water T=0 - 20°C; Schotten-Baumann reaction; 3 h;
参考文献
Peters, Byron K.; Chakka, Sai Kumar; Naicker, Tricia; Maguire, Glenn E.M.; Kruger, Hendrik G.; Andersson, Pher G.; Govender, Thavendran
Tetrahedron Asymmetry, 2010 , vol. 21, # 6 p. 679 - 687
反应条件
1: 70 percent / aq. HCl View Scheme
参考文献
Chimia, , vol. 50, # 11 p. 532 - 537
反应条件
1: 79 percent / conc. H2SO4 / CH2Cl2 / 360 h / Ambient temperature 2: 78 percent / H2 / 5percent Pd/C / methanol / 2 h / Ambient temperature View Scheme
参考文献
Salvadori, Severe; Balboni, Gianfranco; Guerrini, Remo; Tomatis, Roberto; Bianchi, Clementina; Bryant, Sharon D.; Cooper, Peter S.; Lazarus, Lawrence H.
Journal of Medicinal Chemistry, 1997 , vol. 40, # 19 p. 3100 - 3108
反应条件
3: H2 / Pd/C View Scheme
参考文献
Goehring, Wolfgang; Gokhale, Surendra; Hilpert, Hans; Roessler, Felix; Schlageter, Markus; Vogt, Peter
Chimia, 1996 , vol. 50, # 11 p. 532 - 537
反应条件
3: H2 / Pd/C 4: 85 percent / H2 / Rh/Alox / ethyl acetate / 150 °C / 112509 Torr View Scheme
参考文献
Goehring, Wolfgang; Gokhale, Surendra; Hilpert, Hans; Roessler, Felix; Schlageter, Markus; Vogt, Peter
Chimia, 1996 , vol. 50, # 11 p. 532 - 537
反应条件
3: H2 / Pd/C 4: 85 percent / H2 / Rh/Alox / ethyl acetate / 150 °C / 112509 Torr 5: dimethylformamide / 120 °C 6: 1.) MeNH2, 2.) HCl View Scheme
参考文献
Goehring, Wolfgang; Gokhale, Surendra; Hilpert, Hans; Roessler, Felix; Schlageter, Markus; Vogt, Peter
Chimia, 1996 , vol. 50, # 11 p. 532 - 537
反应条件
3: H2 / Pd/C 4: 85 percent / H2 / Rh/Alox / ethyl acetate / 150 °C / 112509 Torr 5: dimethylformamide / 120 °C 6: 1.) MeNH2, 2.) HCl 8: H2 / Pd/C View Scheme
参考文献
Goehring, Wolfgang; Gokhale, Surendra; Hilpert, Hans; Roessler, Felix; Schlageter, Markus; Vogt, Peter
Chimia, 1996 , vol. 50, # 11 p. 532 - 537
反应条件
3: H2 / Pd/C
4: 85 percent / H2 / Rh/Alox / ethyl acetate / 150 °C / 112509 Torr
5: dimethylformamide / 120 °C
6: 1.) MeNH2, 2.) HCl
View Scheme
参考文献
Goehring, Wolfgang; Gokhale, Surendra; Hilpert, Hans; Roessler, Felix; Schlageter, Markus; Vogt, Peter
Chimia, 1996 , vol. 50, # 11 p. 532 - 537
