11-(2-咪唑-1-基乙酰基)-5H-吡啶并[2,3-b][1,4]苯并二氮杂卓-6-酮合成路线 （共 11 条）
反应条件
hydrogen; nickel in ethanol
T=60°C; 8 h;
参考文献
Kovac, T.; Oklobdzija, M.; Comisso, G.; Decorte, E.; Fajdiga, T.; et al.
Journal of Heterocyclic Chemistry, 1983 , vol. 20, p. 1339 - 1349
反应条件
1: 90 percent / 40percent H2O2, acetic acid / 24 h / 55 - 60 °C / bath temperature
2: 8.96 g / conc. NH4OH, CuSO4*5H2O, NaCl / 5 h / 80 °C
3: 96 percent / 5percent aq. HCl / various solvent(s) / 1.5 h / 110 °C / bath temperature
4: acetonitrile / 2 h / 80 °C
5: 100 percent / toluene / 2 h / 80 °C
6: H2 / Raney nickel / ethanol / 8 h / 60 °C
View Scheme
参考文献
Kovac, T.; Oklobdzija, M.; Comisso, G.; Decorte, E.; Fajdiga, T.; et al.
Journal of Heterocyclic Chemistry, 1983 , vol. 20, p. 1339 - 1349
反应条件
1: acetonitrile / 2 h / 80 °C
2: 100 percent / toluene / 2 h / 80 °C
3: H2 / Raney nickel / ethanol / 8 h / 60 °C
View Scheme
参考文献
Kovac, T.; Oklobdzija, M.; Comisso, G.; Decorte, E.; Fajdiga, T.; et al.
Journal of Heterocyclic Chemistry, 1983 , vol. 20, p. 1339 - 1349
反应条件
1: 90 percent / 40percent H2O2, acetic acid / 24 h / 55 - 60 °C / bath temperature
2: conc. NH4OH, CuSO4*5H2O, NaCl / 3 h / 60 °C
3: 96 percent / 5percent aq. HCl / various solvent(s) / 1.5 h / 110 °C / bath temperature
4: acetonitrile / 2 h / 80 °C
5: 100 percent / toluene / 2 h / 80 °C
6: H2 / Raney nickel / ethanol / 8 h / 60 °C
View Scheme
参考文献
Kovac, T.; Oklobdzija, M.; Comisso, G.; Decorte, E.; Fajdiga, T.; et al.
Journal of Heterocyclic Chemistry, 1983 , vol. 20, p. 1339 - 1349
反应条件
1: 96 percent / 5percent aq. HCl / various solvent(s) / 1.5 h / 110 °C / bath temperature
2: acetonitrile / 2 h / 80 °C
3: 100 percent / toluene / 2 h / 80 °C
4: H2 / Raney nickel / ethanol / 8 h / 60 °C
View Scheme
参考文献
Kovac, T.; Oklobdzija, M.; Comisso, G.; Decorte, E.; Fajdiga, T.; et al.
Journal of Heterocyclic Chemistry, 1983 , vol. 20, p. 1339 - 1349
反应条件
1: 8.96 g / conc. NH4OH, CuSO4*5H2O, NaCl / 5 h / 80 °C
2: 96 percent / 5percent aq. HCl / various solvent(s) / 1.5 h / 110 °C / bath temperature
3: acetonitrile / 2 h / 80 °C
4: 100 percent / toluene / 2 h / 80 °C
5: H2 / Raney nickel / ethanol / 8 h / 60 °C
View Scheme
参考文献
Kovac, T.; Oklobdzija, M.; Comisso, G.; Decorte, E.; Fajdiga, T.; et al.
Journal of Heterocyclic Chemistry, 1983 , vol. 20, p. 1339 - 1349
反应条件
1: conc. NH4OH, CuSO4*5H2O, NaCl / 3 h / 60 °C
2: 96 percent / 5percent aq. HCl / various solvent(s) / 1.5 h / 110 °C / bath temperature
3: acetonitrile / 2 h / 80 °C
4: 100 percent / toluene / 2 h / 80 °C
5: H2 / Raney nickel / ethanol / 8 h / 60 °C
View Scheme
参考文献
Kovac, T.; Oklobdzija, M.; Comisso, G.; Decorte, E.; Fajdiga, T.; et al.
Journal of Heterocyclic Chemistry, 1983 , vol. 20, p. 1339 - 1349
反应条件
1: 100 percent / toluene / 2 h / 80 °C
2: H2 / Raney nickel / ethanol / 8 h / 60 °C
View Scheme
参考文献
Kovac, T.; Oklobdzija, M.; Comisso, G.; Decorte, E.; Fajdiga, T.; et al.
Journal of Heterocyclic Chemistry, 1983 , vol. 20, p. 1339 - 1349
反应条件
1: 1) NH4Cl, polyphosphoric acid, 2) H2O / 1) 160 deg C, 4 h, 2) r.t.
2: 95 percent / 40percent H2O2, acetic acid / 50 deg C, 3 h, then 20-25 deg C, 24 h
3: acetonitrile / 2 h / 80 °C
4: 100 percent / toluene / 2 h / 80 °C
5: H2 / Raney nickel / ethanol / 8 h / 60 °C
View Scheme
参考文献
Kovac, T.; Oklobdzija, M.; Comisso, G.; Decorte, E.; Fajdiga, T.; et al.
Journal of Heterocyclic Chemistry, 1983 , vol. 20, p. 1339 - 1349
反应条件
1: 95 percent / 40percent H2O2, acetic acid / 50 deg C, 3 h, then 20-25 deg C, 24 h
2: acetonitrile / 2 h / 80 °C
3: 100 percent / toluene / 2 h / 80 °C
4: H2 / Raney nickel / ethanol / 8 h / 60 °C
View Scheme
参考文献
Kovac, T.; Oklobdzija, M.; Comisso, G.; Decorte, E.; Fajdiga, T.; et al.
Journal of Heterocyclic Chemistry, 1983 , vol. 20, p. 1339 - 1349
