4-己氧基-3-甲氧基苯甲酸酯合成路线 （共 6 条）
反应条件
1: With sodium hydroxide; ethanol; water
T=0 - 20°C; 15 h;
2: With hydrogenchloride in water
T=0°C;
参考文献
TANABE SEIYAKU CO., LTD.
Patent: WO2006/80477 A1, 2006 ;
Location in patent: Page/Page column 27; 53 ;
反应条件
potassium permanganate
参考文献
Pearl
Journal of the American Chemical Society, 1955 , vol. 77, p. 757
反应条件
sodium hydroxide in various solvent(s)
0.25 h;
参考文献
Sawyer, David A.; Beams, Richard M.; Blackwell, Geoffrey, J.; Brockwell, Michael A.; Cheesman, Neil J.; et al.
Journal of Medicinal Chemistry, 1995 , vol. 38, # 12 p. 2130 - 2137
反应条件
1: Bu4NHSO4, K2CO3 / toluene / 6 h / Heating
2: 2M aq. NaOH / various solvent(s) / 0.25 h
View Scheme
参考文献
Sawyer, David A.; Beams, Richard M.; Blackwell, Geoffrey, J.; Brockwell, Michael A.; Cheesman, Neil J.; et al.
Journal of Medicinal Chemistry, 1995 , vol. 38, # 12 p. 2130 - 2137
反应条件
1: Bu4NHSO4, K2CO3 / toluene / 6 h / Heating
2: 2M aq. NaOH / various solvent(s) / 0.25 h
View Scheme
参考文献
Sawyer, David A.; Beams, Richard M.; Blackwell, Geoffrey, J.; Brockwell, Michael A.; Cheesman, Neil J.; et al.
Journal of Medicinal Chemistry, 1995 , vol. 38, # 12 p. 2130 - 2137
反应条件
potassium hydroxide in ethanol; water
25 h; Heating;
参考文献
Kasuga, Kazuyuki; Hatakeyama, Hyoe; Hatakeyama, Tatsuko
Molecular Crystals and Liquid Crystals (1969-1991), 1987 , vol. 147, p. 1 - 14
