3-二甲基氨基氮杂丁烷-1-羧酸叔丁酯合成路线 （共 5 条）
反应条件
1: With hydrogen; acetic acid; palladium 10 on activated carbon in tetrahydrofuran; methanol
T=20°C; 14 h;
2: With sodium hydrogencarbonate in water; ethyl acetate
参考文献
Eisai RandD Management Co., Ltd.
Patent: EP1889836 A1, 2008 ;
Location in patent: Page/Page column 39; 40 ;
反应条件
triethylamine in dichloromethane
T=0 - 20°C; 5 h;
参考文献
ASTRAZENECA AB; ASTRAZENECA UK LIMITED; BUTTERWORTH, Sam; FINLAY, Maurice, Raymond, Verschoyle; WARD, Richard, Andrew; KADAMBAR, Vasantha, Krishna; CHANDRASHEKAR, Reddy, C.; MURUGAN, Andiappan; REDFEARN, Heather, Marie
Patent: WO2013/14448 A1, 2013 ;
Location in patent: Page/Page column 95 ;
WO 2013/014448 A1
反应条件
in ethanol
T=80°C; 28 h;
参考文献
PFIZER LIMITED; PFIZER INC.
Patent: WO2004/96810 A1, 2004 ;
Location in patent: Page 240 ;
反应条件
1.1: 1-chloroethyl chlorocarbonate / 1,2-dichloro-ethane / 2 h / 100 °C
1.2: 2 h / 90 °C
2.1: triethylamine / dichloromethane / 5 h / 0 - 20 °C
View Scheme
参考文献
ASTRAZENECA AB; ASTRAZENECA UK LIMITED; BUTTERWORTH, Sam; FINLAY, Maurice, Raymond, Verschoyle; WARD, Richard, Andrew; KADAMBAR, Vasantha, Krishna; CHANDRASHEKAR, Reddy, C.; MURUGAN, Andiappan; REDFEARN, Heather, Marie
Patent: WO2013/14448 A1, 2013 ;
WO 2013/014448 A1
反应条件
hydrogenchloride in diethyl ether
T=20°C; 0.666667 h;
参考文献
ASTRAZENECA AB; ASTRAZENECA UK LIMITED; BUTTERWORTH, Sam; FINLAY, Maurice, Raymond, Verschoyle; WARD, Richard, Andrew; KADAMBAR, Vasantha, Krishna; CHANDRASHEKAR, Reddy, C.; MURUGAN, Andiappan; REDFEARN, Heather, Marie
Patent: WO2013/14448 A1, 2013 ;
Location in patent: Page/Page column 94; 95 ;
WO 2013/014448 A1
