1-(4-三氟甲基苯磺酰基)-哌嗪盐酸盐合成路线 （共 3 条）
反应条件
1: With hydrogenchloride; water in 1,4-dioxane
2: With sodium hydroxide in dichloromethane; water
参考文献
Heer, Jag Paul; Norton, David; Ward, Simon E.
Patent: US2010/16330 A1, 2010 ;
Location in patent: Page/Page column 8 ;
反应条件
triethylamine in dichloromethane
T=20°C;
参考文献
Nettekoven, Matthias; Plancher, Jean-Marc; Richter, Hans; Roche, Olivier; Taylor, Sven
Patent: US2008/188484 A1, 2008 ;
Location in patent: Page/Page column 22 ;
US 20080188484 A1
反应条件
1: triethylamine / dichloromethane / 48 h / 20 °C
2: hydrogenchloride; acetic acid / water / 2 h / 20 °C
View Scheme
参考文献
Berrade, Luis; Aisa, Barbara; Ramirez, Maria J.; Galiano, Silvia; Guccione, Salvatore; Moltzau, Lise Roman; Levy, Finn Olav; Nicoletti, Ferdinando; Battaglia, Giuseppe; Molinaro, Gemma; Aldana, Ignacio; Monge, Antonio; Perez-Silanes, Silvia
Journal of Medicinal Chemistry, 2011 , vol. 54, # 8 p. 3086 - 3090
