3-氨基-7-羟基香豆素合成路线 （共 12 条）
反应条件
1: With sodium nitrite in ethanol 0.25 h; Cooling; 2: With sodium azide in ethanol
参考文献
Jolck, Rasmus I.; Sun, Honghao; Berg, Rolf H.; Andresen, Thomas L.
Chemistry - A European Journal, 2011 , vol. 17, # 12 p. 3326 - 3331
反应条件
1: With hydrogenchloride; water in propan-1-ol
10 h; Heating / reflux;
2: With sodium hydrogencarbonate in propan-1-ol; water
参考文献
Muto, Susumu; Komukai, Masayuki; Itai, Akiko
Patent: US2005/54717 A1, 2005 ;
Location in patent: Page/Page column 7 ;
反应条件
1: With hydrogenchloride; water in ethanol
2 h; Reflux;
2: With sodium hydroxide in ethanol; water
pH=5 - 6; Cooling with ice;
参考文献
Jiang, Jinqiang; Gou, Chao; Luo, Jing; Yi, Chenglin; Liu, Xiaoya
Inorganic Chemistry Communications, 2012 , vol. 15, p. 12 - 15
反应条件
1: With sodium acetate; acetic anhydride
8 h; Reflux;
2: With hydrogenchloride; water in ethanol
2 h; Reflux;
3: With sodium hydroxide in water
pH=5 - 6; Cooling with ice;
参考文献
Yi, Long; Li, Heyang; Sun, Lu; Liu, Liangliang; Zhang, Caihong; Xi, Zhen
Angewandte Chemie, International Edition, 2009 , vol. 48, p. 4034 - 4037
Angewandte Chemie, 2009 , vol. 121, p. 4094 - 4097
反应条件
trifluoroacetic acid in chloroform
T=20°C; 3 h;
参考文献
Kudale, Amit A.; Kendall, Jamie; Warford, C. Chad; Wilkins, Natasha D.; Bodwell, Graham J.
Tetrahedron Letters, 2007 , vol. 48, # 29 p. 5077 - 5080
反应条件
1.1: 21 percent / sodium acetate / 3.5 h / 110 - 120 °C
2.1: 4-(dimethylamino)pyridine / tetrahydrofuran / 0.33 h / 20 °C
2.2: 50 percent / hydrazine hydrate / methanol; tetrahydrofuran / 0.33 h / 20 °C
3.1: 96 percent / TFA / CHCl3 / 3 h / 20 °C
View Scheme
参考文献
Kudale, Amit A.; Kendall, Jamie; Warford, C. Chad; Wilkins, Natasha D.; Bodwell, Graham J.
Tetrahedron Letters, 2007 , vol. 48, # 29 p. 5077 - 5080
反应条件
hydrogenchloride in methanol
Reflux;
参考文献
Soman; Thaker; Rajput
Chemistry of Heterocyclic Compounds, 2011 , vol. 46, # 12 p. 1514 - 1519
反应条件
water; hydrogen iodide; acetic anhydride; acetic acid
T=110°C; 5 h;
参考文献
Matos, Maria Joao; Santana, Lourdes; Uriarte, Eugenio; Serra, Silvia; Corda, Marcella; Fadda, Maria Benedetta; Era, Benedetta; Fais, Antonella
Journal of Pharmacy and Pharmacology, 2012 , vol. 64, # 5 p. 742 - 746
反应条件
1: acetic anhydride; sodium hydride / 3 h / 20 °C
2: 10 palladium on activated charcoal; hydrogen / ethanol / 5 h / 20 °C
3: water; hydrogen iodide; acetic anhydride; acetic acid / 5 h / 110 °C
View Scheme
参考文献
Matos, Maria Joao; Santana, Lourdes; Uriarte, Eugenio; Serra, Silvia; Corda, Marcella; Fadda, Maria Benedetta; Era, Benedetta; Fais, Antonella
Journal of Pharmacy and Pharmacology, 2012 , vol. 64, # 5 p. 742 - 746
反应条件
1: 10 palladium on activated charcoal; hydrogen / ethanol / 5 h / 20 °C
2: water; hydrogen iodide; acetic anhydride; acetic acid / 5 h / 110 °C
View Scheme
参考文献
Matos, Maria Joao; Santana, Lourdes; Uriarte, Eugenio; Serra, Silvia; Corda, Marcella; Fadda, Maria Benedetta; Era, Benedetta; Fais, Antonella
Journal of Pharmacy and Pharmacology, 2012 , vol. 64, # 5 p. 742 - 746
