1: pyridine / 48 h / Ambient temperature 2: 43 h / Ambient temperature; lipase from Pseudomonas cepacia (LAPS) 3: NaOH / H2O / 7 h / Ambient temperature 4: 70 percent / NH4OH / methanol / Ambient temperature View Scheme

1: 1) pyridine, 2) HCl(g) / 1) RT, 48 h, 2a) CHCl3, 0 to 5 deg C, 1 h, 2b) RT, 2 h 2: NaOH / H2O / 7 h / Ambient temperature 3: 70 percent / NH4OH / methanol / Ambient temperature View Scheme