4,4,4-三氟-2-丁炔乙酯合成路线 （共 10 条）
参考文献
Chen, Jian; Lin, Guo-Qiang; Wang, Zhi-Min; Liu, Han-Quan
Synlett, 2002 , # 8 p. 1265 - 1268
反应条件
n-butyllithium; water in anhydrous butyl ether 1) -78 deg C, 1h, 2) r.t., 4h;
参考文献
Tajammal, Sabiha; Tipping, Anthony E.
Journal of Fluorine Chemistry, 1990 , vol. 47, p. 45 - 57
反应条件
water in anhydrous butyl ether 1) -60 deg C, 1h, 2) r.t., 4h; Yield given;
参考文献
Journal of Fluorine Chemistry, , vol. 47, p. 45 - 57
反应条件
sodium methylate 1) MeOH, 20 h, 2) MeOH, H2O, 5 deg C, overnight; Yield given. Multistep reaction;
参考文献
Hamper, Bruce C.; Kurtzweil, Mitchell L.; Beck, James P.
Journal of Organic Chemistry, 1992 , vol. 57, # 21 p. 5680 - 5686
反应条件
air; potassium carbonate in N,N-dimethyl-formamide
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 18, # 6 p. 1958 - 1962
反应条件
in xylene T=100°C; 4 h;
参考文献
WO2006/24820 A1, ;
Page/Page column 124 ;
反应条件
in methanol; water 12 h;
参考文献
Journal of Fluorine Chemistry, , vol. 48, # 1 p. 123 - 131
反应条件
in methanol; water 12 h;
参考文献
Journal of Fluorine Chemistry, , vol. 48, # 1 p. 123 - 131
反应条件
potassium hydroxide; concentrated aqueous KOH in ethanol; water
参考文献
Cytovia, Inc.
Patent: US2003/69239 A1, 2003 ;
US 20030069239 A1
反应条件
1: 60 percent / ethanol / 1 h / 80 °C 2: 71 percent / H2 / 10percent Pd/C / methanol / 24 h / Ambient temperature View Scheme
参考文献
Journal of Fluorine Chemistry, , vol. 73, # 2 p. 161 - 164
