2-羟基-5-三氟甲基苯甲酸合成路线 （共 11 条）
反应条件
oxygen; potassium acetate; palladium diacetate; p-benozquinone in N,N-dimethyl acetamide T=115°C; P=3800.26 Torr; 15 h;
参考文献
THE SCRIPPS RESEARCH INSTITUTE; YU, Jin-quan
Patent: WO2011/37929 A2, 2011 ;
Location in patent: Page/Page column 14; 19-20 ;
反应条件
hydrogenchloride; n-butyllithium; acetic acid in tetrahydrofuran; hexane; water
参考文献
Schafer, Bernd; Geneste, Herve
Patent: US2004/92754 A1, 2004 ;
反应条件
boron trifluoride diethyl etherate in methanol T=25°C; 15 h;
参考文献
Marzi, Elena; Mongin, Florence; Spitaleri, Andrea; Schlosser, Manfred
European Journal of Organic Chemistry, 2001 , # 15 p. 2911 - 2915
反应条件
n-butyllithium; N,N,N',N,-tetramethylethylenediamine; potassium tert-butylate in hexane T=10°C; 0.5 h;
参考文献
Marzi, Elena; Mongin, Florence; Spitaleri, Andrea; Schlosser, Manfred
European Journal of Organic Chemistry, 2001 , # 15 p. 2911 - 2915
反应条件
1-trans-IODO-4-CYCLOHEXYL in N,N-dimethyl-formamide 4 h; Reflux;
参考文献
WO2011/38572 A1, ;
Page/Page column 82 ;
WO 2011/038572 A1
反应条件
1: 3-[4-(trifluoromethyl)phenoyl]tetrahydro-2-H-pyran With n-butyllithium; N,N,N',N,-tetramethylethylenediamine in tetrahydrofuran; hexane T=-20°C; 0.5 h; 2: carbon dioxide in tetrahydrofuran; hexane T=-20 - 20°C; 3: With hydrogenchloride in tetrahydrofuran; hexane
参考文献
Geneste; Schaefer
Synthesis, 2001 , # 15 p. 2259 - 2262
反应条件
1.1: 92 percent / HCl / dioxane; CH2Cl2 / 20 °C 2.1: BuLi; TMEDA / hexane; tetrahydrofuran / 0.5 h / -20 °C 2.2: hexane; tetrahydrofuran / -20 - 20 °C 2.3: 53 percent / aq. HCl / hexane; tetrahydrofuran; various solvent(s) View Scheme
参考文献
Synthesis, , # 15 p. 2259 - 2262
反应条件
boron tribromide in dichloromethane 2 h; Ambient temperature;
参考文献
Yamamoto, Satoshi; Hashiguchi, Shohei; Miki, Shokyo; Igata, Yumiko; Watanabe, Toshifumi; Shiraishi, Mitsuru
Chemical and Pharmaceutical Bulletin, 1996 , vol. 44, # 4 p. 734 - 745
反应条件
1: 54 percent / potassium tert-butoxide; butyllithium / tetrahydrofuran; hexane / 2 h / -75 °C 2: 93 percent / boron trifluoride-diethyl ether / methanol / 15 h / 25 °C View Scheme
参考文献
European Journal of Organic Chemistry, , # 15 p. 2911 - 2915
反应条件
1: 24.4 g / cuprous iodide / dimethylformamide; toluene / 6.5 h / 140 - 160 °C 2: 19 percent / boron tribromide / CH2Cl2 / 2 h / Ambient temperature View Scheme
参考文献
Chemical and Pharmaceutical Bulletin, , vol. 44, # 4 p. 734 - 745
