6-(溴甲基)-2,3-二氢苯并[b][1,4]二噁英合成路线 （共 3 条）
反应条件
carbon tetrabromide; triphenylphosphine in dichloromethane T=20°C; 24 h;
参考文献
EXELIXIS, INC.; CHAN, Wai, Ki, Vicky; DU, Hongwang; KEARNEY, Patrick; KOLTUN, Elena, S.; NACHTIGALL, Jason, August; NOSON, Kevin; PACK, Michael; RICHARDS, Steven, James
Patent: WO2010/91104 A1, 2010 ;
Location in patent: Page/Page column 51 ;
反应条件
1: sodium tetrahydroborate / dichloromethane / 0.5 h / 20 °C 2: phosphorus tribromide / dichloromethane / 0.5 h / 0 °C View Scheme
参考文献
European Journal of Medicinal Chemistry, , vol. 55, p. 125 - 136
反应条件
1: lithium aluminium tetrahydride / tetrahydrofuran / 4 h / -10 - 20 °C / Inert atmosphere 2: phosphorus tribromide / dichloromethane / 2 h / 0 °C View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 54, # 4 p. 1033 - 1058
