1: With lithium aluminium tetrahydride in toluene T=20°C; 1 h; Heating / reflux; 2: With sodium hydroxide; water in toluene Product distribution / selectivity;

1: With hydrogenchloride; hydrogen; palladium 10 on activated carbon in methanol; water 19 h; 2: With sodium hydrogencarbonate in methanol; water

1: With hydrogenchloride; hydrogen; palladium 10 on activated carbon in methanol; water 2 h; 2: With sodium hydrogencarbonate in methanol; water

1: With formic acid; palladium 10 on activated carbon in methanol T=35 - 40°C; 3 h; 2: With sodium hydroxide in water pH=10 - 12;

1: N-ethyl-N,N-diisopropylamine; pyrrolidine; zinc(II) chloride / toluene / 4 h / 90 °C / |Inert atmosphere 2: pyridoxal 5'-phosphate; diisopropylamine; transaminase ATA-013 / dimethyl sulfoxide; water / 45 - 50 °C / pH 10.5 / |Inert atmosphere; |Enzymatic reaction 3: potassium hydrogencarbonate / 24 h / 80 °C / |Inert atmosphere View Scheme

1: N-ethyl-N,N-diisopropylamine; pyrrolidine; zinc(II) chloride / toluene / 4 h / 90 °C / |Inert atmosphere 2: pyridoxal 5'-phosphate; diisopropylamine; transaminase ATA-013 / dimethyl sulfoxide; water / 45 - 50 °C / pH 10.5 / |Inert atmosphere; |Enzymatic reaction 3: potassium hydrogencarbonate / 24 h / 80 °C / |Inert atmosphere View Scheme

1: pyridoxal 5'-phosphate; diisopropylamine; transaminase ATA-013 / dimethyl sulfoxide; water / 45 - 50 °C / pH 10.5 / |Inert atmosphere; |Enzymatic reaction 2: potassium hydrogencarbonate / 24 h / 80 °C / |Inert atmosphere View Scheme

hydrogenchloride; methanol T=0 - 66°C; 2 h; Product distribution / selectivity;

potassium hydrogencarbonate T=80°C; 24 h; Inert atmosphere;

potassium hydrogencarbonate T=80°C; 24 h; Inert atmosphere;