3-氨基甲基-噻吩-2-羧酸甲酯合成路线 (共 3 条)
反应条件
1: H2SO4 / Heating
2: NBS, dibenzoylperoxide / CCl4 / Heating
3: NH3 / dimethylformamide
View Scheme
参考文献
Peschke, Bernd; Madsen, Kjeld; Hansen, Birgit Sehested; Johansen, Nils Langeland
Bioorganic and Medicinal Chemistry Letters, 1997 , vol. 7, # 15 p. 1969 - 1972
反应条件
1: 18 h / Reflux
2: 2,2'-azo-bisisobutyronitrile; N-bromosuccinmide / tetrachloromethane / 3 h / 70 °C / Inert atmosphere; Reflux
3: ammonia / methanol / 14 h / 20 °C / Inert atmosphere
View Scheme
参考文献
GILEAD CONNECTICUT, INC.; GENENTECH, INC.; CURRIE, Kevin S.; WANG, Xiaojing; YOUNG, Wendy B.
Patent: WO2012/31004 A1, 2012 ;
WO 2012/031004 A1
反应条件
potassium carbonate in methanol; ethanol
Reflux;
参考文献
Augeri, David John; Bagdanoff, Jeffrey Thomas; Baugh, Simon David Peter; Carlsen, Marianne; Carson, Kenneth Gordon; Gilleran, John Anthony; He, Wei; Oravecz, Tamas; Salojin, Konstantin; Sung, Leonard
Patent: US2012/225857 A1, 2012 ;
Location in patent: Page/Page column 14 ;