4,5-二氢噻吩并[2,3-c]吡咯-6-酮合成路线 （共 2 条）
反应条件
potassium carbonate in methanol; ethanol
Reflux;
参考文献
Augeri, David John; Bagdanoff, Jeffrey Thomas; Baugh, Simon David Peter; Carlsen, Marianne; Carson, Kenneth Gordon; Gilleran, John Anthony; He, Wei; Oravecz, Tamas; Salojin, Konstantin; Sung, Leonard
Patent: US2012/225857 A1, 2012 ;
Location in patent: Page/Page column 14 ;
反应条件
1: 18 h / Reflux
2: 2,2'-azo-bisisobutyronitrile; N-bromosuccinmide / tetrachloromethane / 3 h / 70 °C / Inert atmosphere; Reflux
3: ammonia / methanol / 14 h / 20 °C / Inert atmosphere
4: bis(trimethylaluminum)-1,4-diazabicyclo[2.2.2]octane / tetrahydrofuran / 14 h / 60 °C / Inert atmosphere
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参考文献
GILEAD CONNECTICUT, INC.; GENENTECH, INC.; CURRIE, Kevin S.; WANG, Xiaojing; YOUNG, Wendy B.
Patent: WO2012/31004 A1, 2012 ;
WO 2012/031004 A1
