4-{[双(β-氯乙基)氨基]苯基}丁酸甲酯合成路线 （共 6 条）
反应条件
1: concd. HCl / 1.) 60 deg C, 30 min, 2.) reflux, 10 min 2: EtOCOCl, Et3N / acetone / 0.25 h / 0 °C 3: aq. NaN3 / acetone / 0.5 h / 0 °C 4: benzene / 1 h / Heating 5: 8 N HCl / 0.17 h / Heating 6: 76 percent / methanol / 24 h / 20 °C View Scheme
参考文献
Valu, Kisione K.; Gourdie, Trudi A.; Boritzki, Theodore J.; Gravatt, G. Lance; Baguley, Bruce C.; et al.
Journal of Medicinal Chemistry, 1990 , vol. 33, # 11 p. 3014 - 3019
反应条件
benzotriazol-1-ol; N-ethyl-N,N-diisopropylamine
T=55°C; 18 h;
参考文献
CINCINNATI CHILDREN'S HOSPITAL MEDICAL CENTER; UNIVERSITY OF CINCINNATI; Merino, Edward J.; Mulloy, James C.; Li, Guorui; Bell-Horwath, Tiffany
Patent: US2013/230542 A1, 2013 ;
Location in patent: Paragraph 0168 ;
反应条件
1: H2 / Pd/C / ethyl acetate
2: AcOH / tetrahydrofuran / 48 h / 110 - 120 °C
3: POCl3 / benzene / 1 h / Heating
View Scheme
参考文献
Valu, Kisione K.; Gourdie, Trudi A.; Boritzki, Theodore J.; Gravatt, G. Lance; Baguley, Bruce C.; et al.
Journal of Medicinal Chemistry, 1990 , vol. 33, # 11 p. 3014 - 3019
反应条件
trichlorophosphate in benzene
1 h; Heating;
参考文献
Valu, Kisione K.; Gourdie, Trudi A.; Boritzki, Theodore J.; Gravatt, G. Lance; Baguley, Bruce C.; et al.
Journal of Medicinal Chemistry, 1990 , vol. 33, # 11 p. 3014 - 3019
反应条件
1: acetic acid
2: phosphorus oxychloride / toluene / Heating
View Scheme
参考文献
Rapp, Maryse; Giraud, Isabelle; Maurizis, Jean-Claude; Madelmont, Jean-Claude
Bioorganic and Medicinal Chemistry, 2003 , vol. 11, # 23 p. 5007 - 5012
反应条件
1: concd. HCl / 1.) 60 deg C, 30 min, 2.) reflux, 10 min
2: EtOCOCl, Et3N / acetone / 0.25 h / 0 °C
3: aq. NaN3 / acetone / 0.5 h / 0 °C
4: benzene / 1 h / Heating
View Scheme
参考文献
Valu, Kisione K.; Gourdie, Trudi A.; Boritzki, Theodore J.; Gravatt, G. Lance; Baguley, Bruce C.; et al.
Journal of Medicinal Chemistry, 1990 , vol. 33, # 11 p. 3014 - 3019
