2,6-二溴-3-甲氧基-5-硝基吡啶合成路线 （共 9 条）
反应条件
hydrazine hydrate; palladium on activated charcoal in ethanol 0.5 h; Heating;
参考文献
Clark, Gary J.; Deady, Leslie W.
Australian Journal of Chemistry, 1981 , vol. 34, # 4 p. 927 - 932
反应条件
sodium 1.) methanol, 2.) reflux, 5 min; Yield given. Multistep reaction. Yields of byproduct given;
参考文献
Barraclough; Black; Cambridge; Collard; Firmin; Gerskowitch; Glen; Giles; Hill; Hull; Iyer; King; Kneen; Lindon; Nobbs; Randall; Shah; Smith; Vine; et al.
Journal of Medicinal Chemistry, 1990 , vol. 33, # 8 p. 2231 - 2239
反应条件
sulfuric acid; nitric acid
T=60 - 65°C; 2 h;
参考文献
Clark, Gary J.; Deady, Leslie W.
Australian Journal of Chemistry, 1981 , vol. 34, # 4 p. 927 - 932
反应条件
1: 44 percent / bromine, aq. NaOH / 1.) 0 deg C, 0.5 h, 2.) RT, 2 h
2: 79 percent / potassium carbonate / dimethylsulfoxide / 1 h / Heating
3: 45 percent / nitric acid, conc. sulfuric acid / 2 h / 60 - 65 °C
View Scheme
参考文献
Clark, Gary J.; Deady, Leslie W.
Australian Journal of Chemistry, 1981 , vol. 34, # 4 p. 927 - 932
反应条件
1: 79 percent / potassium carbonate / dimethylsulfoxide / 1 h / Heating
2: 45 percent / nitric acid, conc. sulfuric acid / 2 h / 60 - 65 °C
View Scheme
参考文献
Clark, Gary J.; Deady, Leslie W.
Australian Journal of Chemistry, 1981 , vol. 34, # 4 p. 927 - 932
反应条件
hydrogen; platinum(IV) oxide in ethanol
P=760 Torr;
参考文献
Clark, Gary J.; Deady, Leslie W.
Australian Journal of Chemistry, 1981 , vol. 34, # 4 p. 927 - 932
反应条件
in methanol
T=20°C; 1 h;
参考文献
4SC AG
Patent: EP2017277 A1, 2009 ;
Location in patent: Page/Page column 30 ;
EP 2017277 A1
反应条件
sodium methylate in methanol
20 h;
参考文献
Clark, Gary J.; Deady, Leslie W.
Australian Journal of Chemistry, 1981 , vol. 34, # 4 p. 927 - 932
反应条件
1: 95 percent / sodium methoxide / methanol / 20 h
2: hydrazine hydrate / Pd/C / ethanol / 0.5 h / Heating
View Scheme
参考文献
Clark, Gary J.; Deady, Leslie W.
Australian Journal of Chemistry, 1981 , vol. 34, # 4 p. 927 - 932
