乙基 N-(2-乙氧基-2-氧代乙基)-N-(苯基甲基)-beta-丙氨酸酯合成路线 （共 7 条）
反应条件
potassium tert-butylate in toluene T=0°C; 2 h;
参考文献
EP1552842 A1, ;
Page/Page column 302 ;
反应条件
potassium carbonate; sodium iodide in butanone
Heating / reflux;
参考文献
KYOWA HAKKO KOGYO CO., LTD.
Patent: EP1552842 A1, 2005 ;
Location in patent: Page/Page column 301 ;
反应条件
in dichloromethane; acetone
参考文献
Colon-Cruz, Roberto; Didiuk, Mary T.; Duffy, Erin M.; Garigipati, Ravi; Lau, Wan F.; McDonald, Wayne S.
Patent: US2003/8893 A1, 2003 ;
US 20030008893 A1
反应条件
triethylamine in dichloromethane
参考文献
THE SCRIPPS RESEARCH INSTITUTE; CARROLL, Kate, S.
Patent: WO2014/89546 A1, 2014 ;
Location in patent: Sheet 23 ;
反应条件
sodium hydrogencarbonate in acetonitrile
T=20°C; 18 h; Inert atmosphere;
参考文献
Allmendinger, Thomas; Bixel, Dominique; Clarke, Adrian; Di Geronimo, Laura; Fredy, Jean-Wilfried; Manz, Marco; Gavioli, Elena; Wicky, Regine; Schneider, Martin; Stauffert, Fabien J.; Tibi, Markus; Valentekovic, Darko
Organic Process Research and Development, 2012 , vol. 16, # 11 p. 1754 - 1769
反应条件
1.1: sodium hydroxide / water / 0.17 h / 0 °C / |Inert atmosphere
1.2: 0 - 20 °C / |Inert atmosphere
2.1: sodium hydrogencarbonate / acetonitrile / 18 h / 20 °C / |Inert atmosphere
View Scheme
参考文献
Allmendinger, Thomas; Bixel, Dominique; Clarke, Adrian; Di Geronimo, Laura; Fredy, Jean-Wilfried; Manz, Marco; Gavioli, Elena; Wicky, Regine; Schneider, Martin; Stauffert, Fabien J.; Tibi, Markus; Valentekovic, Darko
Organic Process Research and Development, 2012 , vol. 16, # 11 p. 1754 - 1769
反应条件
1: sodium ethanolate
2: water / acetonitrile / |Reflux
View Scheme
参考文献
THE SCRIPPS RESEARCH INSTITUTE; CARROLL, Kate, S.
Patent: WO2014/89546 A1, 2014 ;
