4-(3,4-二氯苯基)-4-苯基丁酸合成路线 （共 14 条）
反应条件
1: SOCl2 / toluene / 1.25 h 2: AlCl3 / CS2 / 16 h / Ambient temperature 3: TiCl4 / toluene / 17 h / Ambient temperature 4: sodium borohydride / methanol / 1.5 h / Ambient temperature View Scheme
参考文献
Welch, Willard M.; Kraska, Allen R.; Sarges, Reinhard; Koe, B. Kenneth
Journal of Medicinal Chemistry, 1984 , vol. 27, # 11 p. 1508 - 1515
反应条件
1: SOCl2 / toluene / 1.25 h 2: AlCl3 / CS2 / 16 h / Ambient temperature 3: TiCl4 / toluene / 17 h / Ambient temperature View Scheme
参考文献
Welch, Willard M.; Kraska, Allen R.; Sarges, Reinhard; Koe, B. Kenneth
Journal of Medicinal Chemistry, 1984 , vol. 27, # 11 p. 1508 - 1515
反应条件
1: SOCl2 / toluene / 1.25 h 2: AlCl3 / CS2 / 16 h / Ambient temperature 3: TiCl4 / toluene / 17 h / Ambient temperature 4: sodium borohydride / methanol / 1.5 h / Ambient temperature View Scheme
参考文献
Welch, Willard M.; Kraska, Allen R.; Sarges, Reinhard; Koe, B. Kenneth
Journal of Medicinal Chemistry, 1984 , vol. 27, # 11 p. 1508 - 1515
反应条件
boron trifluoride diethyl etherate; trifluoroacetic anhydride in dichloromethane T=40 - 45°C; 5 h; Product distribution / selectivity;
参考文献
UNICHEM LABORATORIES LIMITED
Patent: WO2007/119247 A2, 2007 ;
Location in patent: Page/Page column 22 ;
反应条件
hydrogen; palladium on activated charcoal in ethyl acetate
P=760 Torr; 24 h; Ambient temperature;
参考文献
Welch, Willard M.; Kraska, Allen R.; Sarges, Reinhard; Koe, B. Kenneth
Journal of Medicinal Chemistry, 1984 , vol. 27, # 11 p. 1508 - 1515
反应条件
hydrogenchloride; aluminium trichloride in benzene
参考文献
Pfizer Inc.
Patent: US4777288 A1, 1988 ;
反应条件
potassium hydroxide in ethanol; water
3 h; Reflux;
参考文献
Pastre, Julio Cezar; Correia, Carlos Roque Duarte
Advanced Synthesis and Catalysis, 2009 , vol. 351, # 9 p. 1217 - 1223
反应条件
aluminium trichloride in dichloromethane
2 h; Ambient temperature;
参考文献
Quallich, George J.; Williams, Michael T.; Friedmann, Robert C.
Journal of Organic Chemistry, 1990 , vol. 55, # 16 p. 4971 - 4973
反应条件
1: potassium tert-butoxide / 2-methyl-propan-2-ol / 16 h / Heating
2: 50 percent / 48percent aq. HBr / acetic acid / 36 h / Heating
3: 100 percent / H2 / 5percent Pd/C / ethyl acetate / 24 h / 760 Torr / Ambient temperature
View Scheme
参考文献
Welch, Willard M.; Kraska, Allen R.; Sarges, Reinhard; Koe, B. Kenneth
Journal of Medicinal Chemistry, 1984 , vol. 27, # 11 p. 1508 - 1515
反应条件
1: 50 percent / 48percent aq. HBr / acetic acid / 36 h / Heating
2: 100 percent / H2 / 5percent Pd/C / ethyl acetate / 24 h / 760 Torr / Ambient temperature
View Scheme
参考文献
Welch, Willard M.; Kraska, Allen R.; Sarges, Reinhard; Koe, B. Kenneth
Journal of Medicinal Chemistry, 1984 , vol. 27, # 11 p. 1508 - 1515
