4-(3,4-二氯苯基)-1-四氢萘酮合成路线 （共 39 条）
反应条件
1: 100 percent / H2 / 5percent Pd/C / ethyl acetate / 24 h / 760 Torr / Ambient temperature 2: SOCl2 / toluene / 1.25 h 3: AlCl3 / CS2 / 16 h / Ambient temperature View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 27, # 11 p. 1508 - 1515
反应条件
1: 50 percent / 48percent aq. HBr / acetic acid / 36 h / Heating 2: 100 percent / H2 / 5percent Pd/C / ethyl acetate / 24 h / 760 Torr / Ambient temperature 3: SOCl2 / toluene / 1.25 h 4: AlCl3 / CS2 / 16 h / Ambient temperature View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 27, # 11 p. 1508 - 1515
反应条件
hydrogen fluoride 18 h; Ambient temperature;
参考文献
Quallich, George J.; Williams, Michael T.; Friedmann, Robert C.
Journal of Organic Chemistry, 1990 , vol. 55, # 16 p. 4971 - 4973
反应条件
trifluorormethanesulfonic acid T=50°C; Friedel Crafts acylation; 16 h; Inert atmosphere;
参考文献
Raja, Erum K.; Deschepper, Daniel J.; Nilsson Lill, Sten O.; Klumpp, Douglas A.
Journal of Organic Chemistry, 2012 , vol. 77, # 13 p. 5788 - 5793
反应条件
aluminium trichloride in carbon disulfide 16 h; Ambient temperature; Yield given;
参考文献
Journal of Medicinal Chemistry, , vol. 27, # 11 p. 1508 - 1515
反应条件
1: aq. NaOH (pH 10.73), NaBH4 / 2 h / 78 °C 2: aq. HCl / 1) 65 - 70 deg C, 4 h, 2) rt, 16 h 3: 97 percent / anh. hydrogen fluoride / 18 h / Ambient temperature View Scheme
参考文献
Journal of Organic Chemistry, , vol. 55, # 16 p. 4971 - 4973
反应条件
1: aq. HCl / 1) 65 - 70 deg C, 4 h, 2) rt, 16 h 2: 97 percent / anh. hydrogen fluoride / 18 h / Ambient temperature View Scheme
参考文献
Journal of Organic Chemistry, , vol. 55, # 16 p. 4971 - 4973
反应条件
1: 92 percent / AlCl3 / 2.5 h / 60 °C 2: aq. NaOH (pH 10.73), NaBH4 / 2 h / 78 °C 3: aq. HCl / 1) 65 - 70 deg C, 4 h, 2) rt, 16 h 4: 97 percent / anh. hydrogen fluoride / 18 h / Ambient temperature View Scheme
参考文献
Journal of Organic Chemistry, , vol. 55, # 16 p. 4971 - 4973
反应条件
1: With sodium acetate in ethanol 15 h; Reflux; 2: With Lindlar catalyst; hydrogen in methanol; dichloromethane T=20°C; P=760.051 Torr; 20 h;
参考文献
Roesner, Stefan; Casatejada, Javier Mansilla; Elford, Tim G.; Sonawane, Ravindra P.; Aggarwal, Varinder K.
Organic Letters, 2011 , vol. 13, # 21 p. 5740 - 5743
反应条件
1: BH3*Me2S / (S)-prolinol core-containing second-generation dendrimer / tetrahydrofuran / 0.8 h 2: PCC / CH2Cl2 / 0 - 20 °C 3: TiCl4 / diethyl ether / -78 - 20 °C 4: H2; Raney-Ni / methanol View Scheme
参考文献
Lautens, Mark; Rovis, Tomislav
Journal of Organic Chemistry, 1997 , vol. 62, # 16 p. 5246 - 5247
