4-(3,4-二氯苯基)-1-四氢萘酮合成路线 （共 39 条）
反应条件
1: With potassium hydroxide in methanol T=25 - 30°C; 24 h; 2: With sodium tetrahydroborate in methanol T=-5 - 25°C; 12 - 14 h;
参考文献
WO2007/119247 A2, ;
Page/Page column 23 ;
反应条件
potassium formiate; lithium chloride T=145 - 155°C; 10 h;
参考文献
WO2003/99761 A1, ;
Page 4; 10 ;
反应条件
hydroxylamine hydrochloride; sodium acetate in ethanol; water 4 h; RefluxIndustrial scale;
参考文献
Vukics, Krisztina; Fodor, Tamas; Fischer, Janos; Fellegvari, Iren; Levai, Sandor
Organic Process Research and Development, 2002 , vol. 6, # 1 p. 82 - 85
反应条件
1: 91 percent / TiCl4 / diethyl ether / -35 - 20 °C
2: (R,R)-(ethylenebis(tetrahydroindenyl))TiF2; PhSiH3 / tetrahydrofuran / 5 h / 20 °C
View Scheme
参考文献
Yun, Jaesook; Buchwald, Stephen L.
Journal of Organic Chemistry, 2000 , vol. 65, # 3 p. 767 - 774
反应条件
chiral HPLC
Resolution of racemate; optical yield given as percent ee;
参考文献
Chen, Fei; Wang, Tianli; He, Yanmei; Ding, Ziyuan; Li, Zhiwei; Xu, Lijin; Fan, Qing-Hua
Chemistry - A European Journal, 2011 , vol. 17, # 4 p. 1109 - 1113
反应条件
1.1: sodium acetate / ethanol; water / 6 h / |Reflux; |Industrial scale
2.1: hydrogen / methanol / 25 °C / 760.05 Torr / |Industrial scale
2.2: |Industrial scale
3.1: ethanol / 25 °C / |Resolution of racemate; |Industrial scale
View Scheme
参考文献
Taber, Geraldine P.; Pfisterer, David M.; Colberg, Juan C.
Organic Process Research and Development, 2004 , vol. 8, # 3 p. 385 - 388
反应条件
1: BH3*Me2S / (S)-prolinol core-containing second-generation dendrimer / tetrahydrofuran / 0.8 h
2: PCC / CH2Cl2 / 0 - 20 °C
View Scheme
参考文献
Chen, Fei; Ding, Ziyuan; He, Yanmei; Qin, Jie; Wang, Tianli; Fan, Qing-Hua
Tetrahedron, 2012 , vol. 68, # 26 p. 5248 - 5257
反应条件
chiral HPLC
Resolution of racemate; optical yield given as percent ee;
参考文献
Chen, Fei; Wang, Tianli; He, Yanmei; Ding, Ziyuan; Li, Zhiwei; Xu, Lijin; Fan, Qing-Hua
Chemistry - A European Journal, 2011 , vol. 17, # 4 p. 1109 - 1113
反应条件
sodium borohydride; triethylamine; methylamine; titanium tetrachloride in methanol; hexane; ethyl acetate; toluene
参考文献
Pfizer Inc.
Patent: US4556676 A1, 1985 ;
US 4556676 A
