4,4-二甲基-2-(4-甲基苯基)-4,5-二氢-1,3-恶唑合成路线 （共 11 条）
反应条件
1: 34 percent / TFA, Et4NOTs / dimethylformamide / Ambient temperature; electrolysis, Pb-cathode, C-anode 2: 1N HCl / Heating View Scheme
参考文献
Shono; Kise; Nomura; Yamanami
Tetrahedron Letters, 1993 , vol. 34, # 22 p. 3577 - 3580
参考文献
Mallory, Frank B.; Butler, Kelly E.; Evans, Amanda C.; Brondyke, Emilie J.; Mallory, Clelia W.; Yang, Changqing; Ellenstein, Aviva
Journal of the American Chemical Society, 1997 , vol. 119, # 9 p. 2119 - 2124
反应条件
1: in chloroform
T=80°C; P=206.859 - 517.148 Torr; 0.166667 h; microwave irradiation;
2: With thionyl chloride in chloroform
T=80°C; 0.0333333 h; microwave irradiation;
参考文献
Katritzky, Alan R.; Cai, Chunming; Suzuki, Kazuyuki; Singh, Sandeep K.
Journal of Organic Chemistry, 2004 , vol. 69, # 3 p. 811 - 814
反应条件
[bis(2-methoxyethyl)amino]-sulfur trifluoride in dichloromethane
T=0°C; 0.5 h;
参考文献
Kangani, Cyrous O.; Kelley, David E.
Tetrahedron Letters, 2005 , vol. 46, # 51 p. 8917 - 8920
反应条件
C2H3O2(1-)*C20H30OP(1-)*C20H31OP*Pd(2+); lithium tert-butylate in N,N-dimethyl acetamide
T=100°C; 14 h; Inert atmosphere;
参考文献
Ackermann, Lutz; Barfuesser, Sebastian; Kornhaass, Christoph; Kapdi, Anant R.
Organic Letters, 2011 , vol. 13, # 12 p. 3082 - 3085
反应条件
(1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride in diethyl ether
16 h; Ambient temperature;
参考文献
Pridgen, Lendon N.; Killmer, Lewis B.
Journal of Organic Chemistry, 1981 , vol. 46, # 26 p. 5402 - 5404
反应条件
Kaolinitic clay
T=165°C; 24 h;
参考文献
Jnaneshwara; Deshpande; Lalithambika; Ravindranathan; Bedekar
Tetrahedron Letters, 1998 , vol. 39, # 5-6 p. 459 - 462
反应条件
NiCl2((PPh3)P)2 in diethyl ether
T=35°C; 16 h;
参考文献
Pridgen, Lendon N.; Killmer, Lewis B.
Journal of Organic Chemistry, 1981 , vol. 46, # 26 p. 5402 - 5404
反应条件
1.1: SOCl2 / 0.5 h / 25 °C
1.2: 2 h / 25 °C
2.1: CHCl3 / 0.17 h / 80 °C / 206.86 - 517.15 Torr / microwave irradiation
2.2: 98 percent / SOCl2 / CHCl3 / 0.03 h / 80 °C / microwave irradiation
View Scheme
参考文献
Katritzky, Alan R.; Cai, Chunming; Suzuki, Kazuyuki; Singh, Sandeep K.
Journal of Organic Chemistry, 2004 , vol. 69, # 3 p. 811 - 814
反应条件
in chloroform
T=25°C; 12 h;
参考文献
Katritzky, Alan R.; Cai, Chunming; Suzuki, Kazuyuki; Singh, Sandeep K.
Journal of Organic Chemistry, 2004 , vol. 69, # 3 p. 811 - 814
